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Literature summary extracted from

  • Lechner, H.; Soriano, P.; Poschner, R.; Hailes, H.C.; Ward, J.M.; Kroutil, W.
    Library of norcoclaurine synthases and their immobilization for biocatalytic transformations (2018), Biotechnol. J., 13, e1700542 .
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.1.78 synthesis the enzyme is a highly suitable catalyst for the Pictet-Spengler reaction Argemone mexicana
4.2.1.78 synthesis the enzyme is a highly suitable catalyst for the Pictet-Spengler reaction Corydalis saxicola
4.2.1.78 synthesis the enzyme is a highly suitable catalyst for the Pictet-Spengler reaction. The enzyme is successfully immobilized on various carriers whereby EziG3 proves to be the best suited for biotransformations Papaver bracteatum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.78 expression in Escherichia coli BL21 (DE3) Argemone mexicana
4.2.1.78 expression in Escherichia coli BL21 (DE3) Corydalis saxicola
4.2.1.78 expression in Escherichia coli BL21 (DE3). Under certain conditions lyophilized whole Escherichia coli cells containing the overexpressed enzyme turn out to a suitable catalysts Papaver bracteatum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine Papaver bracteatum the enzyme is involved in the biosynthesis of benzylisoquinoline (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine Argemone mexicana the enzyme is involved in the biosynthesis of benzylisoquinoline (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine Corydalis saxicola the enzyme is involved in the biosynthesis of benzylisoquinoline (S)-norcoclaurine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.78 Argemone mexicana D2SMN1
-
-
4.2.1.78 Argemone mexicana D2SMN3
-
-
4.2.1.78 Corydalis saxicola F5C449
-
-
4.2.1.78 Papaver bracteatum C3SBT7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.78
-
 Papaver bracteatum
4.2.1.78
-
 Argemone mexicana
4.2.1.78
-
 Corydalis saxicola

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine
-
 Papaver bracteatum (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine
-
 Argemone mexicana (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine
-
 Corydalis saxicola (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine the enzyme is involved in the biosynthesis of benzylisoquinoline Papaver bracteatum (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine the enzyme is involved in the biosynthesis of benzylisoquinoline Argemone mexicana (S)-norcoclaurine + H2O
-
 ?
4.2.1.78 4-hydroxyphenylacetaldehyde + dopamine the enzyme is involved in the biosynthesis of benzylisoquinoline Corydalis saxicola (S)-norcoclaurine + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.78 AmNCS1
-
 Argemone mexicana
4.2.1.78 AmNCS2
-
 Argemone mexicana
4.2.1.78 CsNCS
-
 Corydalis saxicola
4.2.1.78 PbNCS
-
 Papaver bracteatum

General Information

EC Number General Information Comment Organism
4.2.1.78 metabolism the enzyme is involved in the biosynthesis of benzylisoquinoline Argemone mexicana
4.2.1.78 metabolism the enzyme is involved in the biosynthesis of benzylisoquinoline Corydalis saxicola
4.2.1.78 metabolism the enzyme is involved in the biosynthetic of benzylisoquinoline Papaver bracteatum