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Literature summary extracted from

  • Mori, H.; Wada, R.; Li, J.; Ishimoto, T.; Mizuguchi, M.; Obita, T.; Gouda, H.; Hirono, S.; Toyooka, N.
    In silico and pharmacological screenings identify novel serine racemase inhibitors (2014), Bioorg. Med. Chem. Lett., 24, 3732-3735 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.1.1.18 malonate
-
Homo sapiens
5.1.1.18 additional information in silico and pharmacological inhibitor screenings, enzyme homology modeling, four active sites of hSR (two malonate-bound and two ligand-free forms) are used in this protein structure-based virtual screening, ligand docking Homo sapiens
5.1.1.18 N-(4-bromophenyl)-N2-[(4-fluorophenoxy)acetyl]glycinamide
-
Homo sapiens
5.1.1.18 N2-[(4-bromophenoxy)acetyl]-N-(2,6-difluorophenyl)glycinamide
-
Homo sapiens
5.1.1.18 N2-[(4-bromophenoxy)acetyl]-N-(4-iodophenyl)glycinamide
-
Homo sapiens
5.1.1.18 N2-[(4-fluorophenoxy)acetyl]-N-(4-iodophenyl)glycinamide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.1.18 L-serine Homo sapiens
-
D-serine
-
r

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.18 Homo sapiens Q9GZT4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.1.18 L-serine
-
Homo sapiens D-serine
-
r

Synonyms

EC Number Synonyms Comment Organism
5.1.1.18 hSR
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.1.1.18 pyridoxal 5'-phosphate
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.1.1.18 1.31
-
pH and temperature not specified in the publication Homo sapiens malonate

General Information

EC Number General Information Comment Organism
5.1.1.18 additional information homology modeling of the ligand-free form of the human enzyme, in which the X-ray crystal structure of ligand-free rat enzyme, PDB ID 3HMK, is used as a template Homo sapiens