EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.1.1.18 | malonate | - |
Homo sapiens | |
5.1.1.18 | additional information | in silico and pharmacological inhibitor screenings, enzyme homology modeling, four active sites of hSR (two malonate-bound and two ligand-free forms) are used in this protein structure-based virtual screening, ligand docking | Homo sapiens | |
5.1.1.18 | N-(4-bromophenyl)-N2-[(4-fluorophenoxy)acetyl]glycinamide | - |
Homo sapiens | |
5.1.1.18 | N2-[(4-bromophenoxy)acetyl]-N-(2,6-difluorophenyl)glycinamide | - |
Homo sapiens | |
5.1.1.18 | N2-[(4-bromophenoxy)acetyl]-N-(4-iodophenyl)glycinamide | - |
Homo sapiens | |
5.1.1.18 | N2-[(4-fluorophenoxy)acetyl]-N-(4-iodophenyl)glycinamide | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.1.18 | L-serine | Homo sapiens | - |
D-serine | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.1.1.18 | Homo sapiens | Q9GZT4 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.1.18 | L-serine | - |
Homo sapiens | D-serine | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.1.1.18 | hSR | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
5.1.1.18 | pyridoxal 5'-phosphate | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
5.1.1.18 | 1.31 | - |
pH and temperature not specified in the publication | Homo sapiens | malonate |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.1.1.18 | additional information | homology modeling of the ligand-free form of the human enzyme, in which the X-ray crystal structure of ligand-free rat enzyme, PDB ID 3HMK, is used as a template | Homo sapiens |