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Literature summary extracted from

  • Makino, R.; Obata, Y.; Tsubaki, M.; Iizuka, T.; Hamajima, Y.; Kato-Yamada, Y.; Mashima, K.; Shiro, Y.
    Mechanistic insights into the activation of soluble guanylate cyclase by carbon monoxide a multistep mechanism proposed for the BAY 41-2272 induced formation of 5-coordinate CO-heme (2018), Biochemistry, 57, 1620-1631 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 2'-deoxy-3'-GMP the addition of the effector to CO-activated enzyme causes the original 6-coordinate CO-heme to convert to an end product that is an equimolar mixture of a 5- and a new 6-coordinate CO-heme Bos taurus
4.6.1.2 BAY 41-2272 the addition of the effector to CO-activated enzyme causes the original 6-coordinate CO-heme to convert to an end product that is an equimolar mixture of a 5- and a new 6-coordinate CO-heme Bos taurus
4.6.1.2 CO ferrous soluble guanylate cyclase binds CO as two reversible steps. The primary step leads to the full conversion of the ferrous enzyme to the 6-coordinate CO-heme, followed by the slower second step leading to a partial conversion of the 6-coordinate CO-heme to the 5-coordinate CO-heme. Reaction may folow a multistep mechanism, in which the 5-coordinate CO-heme is led by CO release from a putative bis-carbonyl intermediate that is likely provided by the binding of a second CO to the 6-coordinate CO-heme Bos taurus
4.6.1.2 Foscarnet the addition of the effector to CO-activated enzyme causes the original 6-coordinate CO-heme to convert to an end product that is an equimolar mixture of a 5- and a new 6-coordinate CO-heme Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Bos taurus
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-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.2 from lung tissue Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 lung
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Bos taurus
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