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Literature summary extracted from

  • Beaumelle, B.D.; Vial, H.J.
    Acyl-CoA synthetase activity in Plasmodium knowlesi-infected erythrocytes displays peculiar substrate specificities (1988), Biochim. Biophys. Acta, 958, 1-9.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.3 ATP above 13.3 mM Plasmodium knowlesi
6.2.1.3 diphosphate low inhibition of oleoyl-CoA synthesis Plasmodium knowlesi
6.2.1.3 oleoyl-CoA inhibition of oleoyl-CoA synthesis Plasmodium knowlesi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.3 0.011
-
 palmitate
-
 Plasmodium knowlesi
6.2.1.3 0.028
-
 stearate
-
 Plasmodium knowlesi
6.2.1.3 0.03
-
 oleate
-
 Plasmodium knowlesi
6.2.1.3 0.041
-
 linoleate
-
 Plasmodium knowlesi
6.2.1.3 0.048
-
 CoA
-
 Plasmodium knowlesi
6.2.1.3 0.059
-
 arachidonate
-
 Plasmodium knowlesi
6.2.1.3 0.73
-
 ATP
-
 Plasmodium knowlesi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.3 Mg2+ required Plasmodium knowlesi
6.2.1.3 Mg2+ Km: 1.554 Plasmodium knowlesi

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Plasmodium knowlesi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 erythrocyte of Macaca mulatta or Macaca fascicularis infected with Plasmodium knowlesi Plasmodium knowlesi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + arachidonate + CoA
-
 Plasmodium knowlesi AMP + diphosphate + arachidonoyl-CoA
-
 ?
6.2.1.3 ATP + linoleate + CoA
-
 Plasmodium knowlesi AMP + diphosphate + linoleoyl-CoA
-
 ?
6.2.1.3 ATP + oleate + CoA
-
 Plasmodium knowlesi AMP + diphosphate + oleoyl-CoA
-
 ?
6.2.1.3 ATP + palmitate + CoA
-
 Plasmodium knowlesi AMP + diphosphate + palmitoyl-CoA
-
 ?
6.2.1.3 ATP + stearate + CoA
-
 Plasmodium knowlesi AMP + diphosphate + stearoyl-CoA
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.2.1.3 45
-
 half-life of palmitoyl-CoA synthetase activity: 18 min, half-life of oleoyl-CoA synthetase activity: 4 min, half-life of arachidonyl-CoA synthetase activity: 49 min Plasmodium knowlesi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.3 7.5 8.5
-
 Plasmodium knowlesi

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.2.1.3 6.5 8.8 6.5: about 50% of maximal activity, 8.8: about 70% of maximal activity Plasmodium knowlesi