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Literature summary extracted from

  • Paventi, G.; Pizzuto, R.; Passarella, S.
    The occurrence of L-lactate dehydrogenase in the inner mitochondrial compartment of pig liver (2017), Biochem. Biophys. Res. Commun., 489, 255-261 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 oxamate 0.1 mM, inhibition of NADH oxidation rate by about 60% Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.27 additional information
-
 pyruvate the enzyme shows hyperbolic dependence on the substrate concentration Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.27 mitochondrion mL-LDH is restricted in inner compartment Sus scrofa 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.27 35000
-
 SDS-PAGE Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.27 liver
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.27 additional information
-
 the enzyme shows hyperbolic dependence on the substrate concentration Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 pyruvate + NADH + H+
-
 Sus scrofa (S)-lactate + NAD+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.27 mL-LDH
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.27 25
-
 assay at Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.27 additional information
-
 pyruvate the enzyme shows hyperbolic dependence on the substrate concentration Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.27 7.2
-
-
 Sus scrofa