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Literature summary extracted from
- Characterization of microsomal prostaglandin E synthase 1 inhibitors (2014), Basic Clin. Pharmacol. Toxicol., 114, 64-69 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.3 | AF3442 | - |
Homo sapiens |  |
| 5.3.99.3 | AF3485 | - |
Homo sapiens | |
| 5.3.99.3 | MF63 | i.e. 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile | Homo sapiens | |
| 5.3.99.3 | PF-9184 | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.99.3 | microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.3 | Prostaglandin H2 | Homo sapiens | - |
Prostaglandin E2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.3 | Homo sapiens | O14684 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.3 | Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.99.3 | mPGES-1 | - |
Homo sapiens |
| 5.3.99.3 | prostaglandin E synthase 1 | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 5.3.99.3 | 0.0000013 | - |
pH and temperature not specified in the publication | Homo sapiens | MF63 | |
| 5.3.99.3 | 0.00041 | - |
pH and temperature not specified in the publication | Homo sapiens | AF3442 | |
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