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Literature summary extracted from

  • Yan, S.; Yang, X.F.; Liu, H.L.; Fu, N.; Ouyang, Y.; Qing, K.
    Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases an update (2015), World J. Gastroenterol., 21, 3492-3498 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 endoplasmic reticulum isoform ACSL3 Mus musculus 5783
-
6.2.1.3 mitochondrion isoform ACSL5 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + a long-chain fatty acid + CoA Mus musculus
-
 AMP + diphosphate + a long-chain acyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Mus musculus P41216
-
-
6.2.1.3 Mus musculus Q8JZR0
-
-
6.2.1.3 Mus musculus Q91WC3
-
-
6.2.1.3 Mus musculus Q9CZW4
-
-
6.2.1.3 Mus musculus Q9QUJ7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 adrenal gland isoform ACSL4 Mus musculus
-
6.2.1.3 fetus isoform ACSL3 Mus musculus
-
6.2.1.3 liver isoform ACSL1 Mus musculus
-
6.2.1.3 small intestine isoform ACSL5 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + a long-chain fatty acid + CoA
-
 Mus musculus AMP + diphosphate + a long-chain acyl-CoA
-
 ?
6.2.1.3 ATP + arachidonate + CoA preferred substrate of isoform ACSL4 Mus musculus AMP + diphosphate + arachidonoyl-CoA
-
 ?
6.2.1.3 ATP + docosahexaenoate + CoA preferred substrate of isoform ACSL6 Mus musculus AMP + diphosphate + docosahexaenoyl-CoA
-
 ?
6.2.1.3 ATP + eicosanoate + CoA preferred substrate of isoform ACSL4 Mus musculus AMP + diphosphate + eicosanoyl-CoA
-
 ?
6.2.1.3 ATP + oleate + CoA preferred substrate of isoform ACSL3 Mus musculus AMP + diphosphate + oleoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL1 isoform Mus musculus
6.2.1.3 ACSL3 isoform Mus musculus
6.2.1.3 ACSL4 isoform Mus musculus
6.2.1.3 ACSL5 isoform Mus musculus
6.2.1.3 ACSL6 isoform Mus musculus
6.2.1.3 long-chain acyl-CoA synthetase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
6.2.1.3 physiological function long-chain acyl-CoA synthetases induce apoptotic cell death via the c-Jun N-terminal kinase pathway Mus musculus