Literature summary extracted from
Ha, J.; Kwon, S.; Hwang, J.H.; Park, D.H.; Kim, T.W.; Kang, D.G.; Yu, G.E.; Park, H.C.; An, S.M.; Kim, C.W.
Squalene epoxidase plays a critical role in determining pig meat quality by regulating adipogenesis, myogenesis, and ROS scavengers (2017), Sci. Rep., 7, 16740 .
Application
EC Number |
Application |
Comment |
Organism |
---|
1.14.14.17 |
nutrition |
expression of myogenic marker genes (Myog, Myod, and Myh4) and adipogenic marker genes (Pparg, Cebpa, and Adipoq) is substantially downregulated in cells transfected with squalene epoxidase siRNA. mRNA expression levels of ROS scavengers, which affect meat quality by altering protein oxidation processes, are significantly downregulated by squalene epoxidase knockdown |
Sus scrofa |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.14.14.17 |
additional information |
identification of single nucleotide polymorphism c.2565 G>T in Berkshire pigs. Homozygous GG pigs express more squalene epoxidase mRNA than GT heterozygous and TT homozygous pigs in longissimus dorsi tissue. The single nucleotide polymorphism is associated with several meat quality traits including backfat thickness, carcass weight, meat colour (yellowness), fat composition, and water-holding capacity |
Sus scrofa |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.14.14.17 |
Sus scrofa |
A7L861 |
- |
- |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
1.14.14.17 |
physiological function |
rates of myogenesis and adipogenesis induced in C2C12 cells and 3T3-L1 cells, respectively, are decreased by squalene epoxidase knockdown. The expression of myogenic marker genes (Myog, Myod, and Myh4) and adipogenic marker genes (Pparg, Cebpa, and Adipoq) is substantially downregulated in cells transfected with squalene epoxidase siRNA. mRNA expression levels of ROS scavengers, which affect meat quality by altering protein oxidation processes, are significantly downregulated by squalene epoxidase knockdown |
Sus scrofa |