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Literature summary extracted from

  • Henke, S.; Cronan, J.
    Successful conversion of the Bacillus subtilis BirA group II biotin protein ligase into a group I ligase (2014), PLoS ONE, 9, e96757 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.3.4.15 DELTA1-81 elimination of N-terminal domain plus part of the central domain, loss of ligase activity Bacillus subtilis
6.3.4.15 DELTA2-63 elimination of N-terminal domain, mutant shows normal ligase activity Bacillus subtilis
6.3.4.15 DELTA2-65 elimination of N-terminal domain, mutant shows normal ligase activity Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.15 Bacillus subtilis P0CI75
-
-
6.3.4.15 Bacillus subtilis 168 P0CI75
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.15 ATP + biotin + AccB-86 AccB, i.e. acetyl-CoA carboxylase biotin carboxyl carrier protein biotin attachment domain Bacillus subtilis AMP + diphosphate + biotinylated AccB-86
-
 ?
6.3.4.15 ATP + biotin + AccB-86 AccB, i.e. acetyl-CoA carboxylase biotin carboxyl carrier protein biotin attachment domain Bacillus subtilis 168 AMP + diphosphate + biotinylated AccB-86
-
 ?
6.3.4.15 ATP + biotin + BLAP BLAP, i.e. biotin/lipoyl attachment protein Bacillus subtilis AMP + diphosphate + biotinylated BLAP
-
 ?
6.3.4.15 ATP + biotin + BLAP BLAP, i.e. biotin/lipoyl attachment protein Bacillus subtilis 168 AMP + diphosphate + biotinylated BLAP
-
 ?
6.3.4.15 ATP + biotin + PyC-77 Pyc-77, i.e. pyruvate carboxylase biotin attachment domain Bacillus subtilis AMP + diphosphate + biotinylated PyC-77
-
 ?
6.3.4.15 ATP + biotin + PyC-77 Pyc-77, i.e. pyruvate carboxylase biotin attachment domain Bacillus subtilis 168 AMP + diphosphate + biotinylated PyC-77
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.15 BirA
-
 Bacillus subtilis

General Information

EC Number General Information Comment Organism
6.3.4.15 physiological function BirA regulates transcription at three genomic sites: bioWAFDBI, yuiG and yhfUTS. The N-terminal DNA binding domain can be deleted from Bacillus subtilis BirA without adverse effects on its ligase function Bacillus subtilis