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Literature summary extracted from

  • Harris, A.; Williamson, N.; Slater, H.; Cox, A.; Abbasi, S.; Foulds, I.; Simonsen, H.; Leeper, F.; Salmond, G.
    The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation (2004), Microbiology, 150, 3547-3560 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.8.14 S-(L-prolyl)-[peptidyl-carrier protein] + electron-transfer flavoprotein Serratia sp.
-
 S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + reduced electron-transfer flavoprotein
-
 ?
1.3.8.14 S-(L-prolyl)-[peptidyl-carrier protein] + electron-transfer flavoprotein Serratia marcescens
-
 S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + reduced electron-transfer flavoprotein
-
 ?
1.3.8.14 S-(L-prolyl)-[peptidyl-carrier protein] + electron-transfer flavoprotein Serratia marcescens ATCC 274
-
 S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + reduced electron-transfer flavoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.14 Serratia marcescens Q5W271
-
-
1.3.8.14 Serratia marcescens ATCC 274 Q5W271
-
-
1.3.8.14 Serratia sp. Q5W271
-
-
6.2.1.53 Serratia sp. ATCC 39006 Q5W263
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.8.14 S-(L-prolyl)-[peptidyl-carrier protein] + electron-transfer flavoprotein
-
 Serratia sp. S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + reduced electron-transfer flavoprotein
-
 ?
1.3.8.14 S-(L-prolyl)-[peptidyl-carrier protein] + electron-transfer flavoprotein
-
 Serratia marcescens S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + reduced electron-transfer flavoprotein
-
 ?
1.3.8.14 S-(L-prolyl)-[peptidyl-carrier protein] + electron-transfer flavoprotein
-
 Serratia marcescens ATCC 274 S-(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + reduced electron-transfer flavoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.8.14 L-prolyl-PCP dehydrogenase
-
 Serratia sp.
1.3.8.14 L-prolyl-PCP dehydrogenase
-
 Serratia marcescens
1.3.8.14 PigA
-
 Serratia sp.
1.3.8.14 PigA
-
 Serratia marcescens
6.2.1.53 PigI
-
 Serratia sp. ATCC 39006

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.8.14 FAD
-
 Serratia sp.
1.3.8.14 FAD
-
 Serratia marcescens

General Information

EC Number General Information Comment Organism
6.2.1.53 physiological function involved in biosynthesis of prodigiosin. PigI is presumed to adenylate proline and transfer the prolyl group to PigG. The prolyl-PigG is then oxidized by PigA Serratia sp. ATCC 39006