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Literature summary extracted from

  • Yamaguchi, N.; Sunto, A.; Goda, T.; Suruga, K.
    Competitive regulation of human intestinal beta-carotene 15,15'-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1alpha and HNF-4alpha (2014), Life Sci., 119, 34-39 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.63 gene BCMO1, overlapping binding sites for HNF-1alpha and HNF-4alpha in the human BCMO1 gene proximal promoter. Endogenous nuclear HNF-1alpha and HNF-4alpha proteins competitively bind these sites in Caco-2 BBe cells. BCMO1 gene expression levels and promoter activity are significantly decreased in HNF-1alpha siRNA-transfected Caco-2 BBe cells. In contrast, HNF-4alpha siRNA-transfected cells exhibit a significant increase in BCMO1 gene expression and promoter activity. Mutation of these overlapping binding sites dramatically decreases BCMO1 promoter activity. Quantitative real-time reverse transcription-PCR enzyme expression analysis and BCMO1 promoter activity analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.63 beta-carotene + O2 Homo sapiens
-
 2 all-trans-retinal
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Homo sapiens Q9HAY6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 Caco-2 BBe cell
-
 Homo sapiens
-
1.13.11.63 intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.63 beta-carotene + O2
-
 Homo sapiens 2 all-trans-retinal
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 Bcmo1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.13.11.63 Homo sapiens endogenous nuclear HNF-1alpha and HNF-4alpha proteins competitively bind these sites in Caco-2 BBe cells. BCMO1 gene expression levels and promoter activity are significantly decreased in HNF-1alpha siRNA-transfected Caco-2 BBe cells. In contrast, HNF-4alpha siRNA-transfected cells exhibit a significant increase in BCMO1 gene expression and promoter activity. Mutation of these overlapping binding sites dramatically decreases BCMO1 promoter activity down
1.13.11.63 Homo sapiens endogenous nuclear HNF-1alpha and HNF-4alpha proteins competitively bind these sites in Caco-2 BBe cells. BCMO1 gene expression levels and promoter activity are significantly decreased in HNF-1alpha siRNA-transfected Caco-2 BBe cells. In contrast, HNF-4alpha siRNA-transfected cells exhibit a significant increase in BCMO1 gene expression and promoter activity. Mutation of these overlapping binding sites dramatically decreases BCMO1 promoter activity up

General Information

EC Number General Information Comment Organism
1.13.11.63 physiological function competitive regulation of human intestinal beta-carotene 15,15'-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1alpha and HNF-4alpha, which are liver-enriched transcription factors that are also expressed in the small intestine, overview Homo sapiens