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Literature summary extracted from

  • Ke, W.; Fang, L.; Jing, H.; Tao, R.; Wang, T.; Li, Y.; Long, S.; Wang, D.; Xiao, S.
    Cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication through enzyme activity-dependent and -independent mechanisms (2017), J. Virol., 91, e00827-17 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.38 expressed in MARC-145 cells Sus scrofa

Protein Variants

EC Number Protein Variants Comment Organism
1.14.99.38 H242Q/H243Q inactive Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2 Sus scrofa
-
 25-hydroxycholesterol + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.38 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.38 alveolar macrophage
-
 Sus scrofa
-
1.14.99.38 PK-15CD163 cell
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2
-
 Sus scrofa 25-hydroxycholesterol + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.38 CH25H
-
 Sus scrofa

Expression

EC Number Organism Comment Expression
1.14.99.38 Sus scrofa porcine reproductive and respiratory syndrome virus infection significantly downregulates the expression of the enzyme in cells down

General Information

EC Number General Information Comment Organism
1.14.99.38 physiological function cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication Sus scrofa