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Literature summary extracted from

  • Jain, V.; Kikuchi, H.; Oshima, Y.; Sharma, A.; Yogavel, M.
    Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase (2014), J. Struct. Funct. Genomics, 15, 181-190 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.15
-
 Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.15 halofuginone
-
 Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.15 cytoplasm
-
 Plasmodium falciparum 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro Plasmodium falciparum
-
 AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.15 Plasmodium falciparum Q8I5R7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.15 amylose bead column chromatography, heparin column chromatography, and Superdex 200 gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro
-
 Plasmodium falciparum AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.1.15 ? x * 58000, SDS-PAGE Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
6.1.1.15 Prolyl-tRNA synthetase
-
 Plasmodium falciparum
6.1.1.15 PRS
-
 Plasmodium falciparum

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.1.1.15 50
-
 melting temperature of the apoprotein Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.15 ATP
-
 Plasmodium falciparum