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Literature summary extracted from

  • Takitani, K.; Miyazaki, H.; Koh, M.; Kishi, K.; Inoue, A.; Tamai, H.
    Dehydroepiandrosterone alters retinol status and expression of the beta-carotene 15,15'-monooxygenase and lecithin retinol acyltransferase genes (2016), J. Nutr. Sci. Vitaminol., 62, 12-18 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.63 gene bco1, quantitative real-time PCR enzyme expression analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.63 beta-carotene + O2 Rattus norvegicus
-
 2 all-trans-retinal
-
 ?
1.13.11.63 beta-carotene + O2 Rattus norvegicus Wistar
-
 2 all-trans-retinal
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Rattus norvegicus G3V7N1
-
-
1.13.11.63 Rattus norvegicus Wistar G3V7N1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 epithelial cell
-
 Rattus norvegicus
-
1.13.11.63 hepatocyte
-
 Rattus norvegicus
-
1.13.11.63 intestine
-
 Rattus norvegicus
-
1.13.11.63 kidney
-
 Rattus norvegicus
-
1.13.11.63 liver
-
 Rattus norvegicus
-
1.13.11.63 lung
-
 Rattus norvegicus
-
1.13.11.63 additional information tissue expression levels of the enzyme with and without dehydroepiandrosterone addition, overview Rattus norvegicus
-
1.13.11.63 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.63 beta-carotene + O2
-
 Rattus norvegicus 2 all-trans-retinal
-
 ?
1.13.11.63 beta-carotene + O2
-
 Rattus norvegicus Wistar 2 all-trans-retinal
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 Bcmo1
-
 Rattus norvegicus
1.13.11.63 beta-carotene 15,15'-monooxygenase
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.13.11.63 Rattus norvegicus expression of enzyme BCMO1 is lower in liver and intestine from dehydroepiandrosterone fed rats but higher in testis and unaffected in lung and kidney compared to controls down
1.13.11.63 Rattus norvegicus expression of enzyme BCMO1 is lower in liver and intestine from dehydroepiandrosterone fed rats but higher in testis and unaffected in lung and kidney compared to controls up

General Information

EC Number General Information Comment Organism
1.13.11.63 metabolism the major fraction of retinol (recovered as retinyl esters) and carotinoids are packed into chylomicrons, which are released into the lymphocytic circulation Rattus norvegicus
1.13.11.63 physiological function after absorption by the intestinal epithelial cells, a portion of the beta-carotene is cleaved to retinal by enzyme BCMO, which is the major beta-carotene-metabolizing enzyme and has a critical role in maintaining retinol levels Rattus norvegicus