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Literature summary extracted from

  • Luis, P.; Ruiter, J.; IJlst, L.; De Almeida, I.; Duran, M.; Wanders, R.; Silva, M.
    Valproyl-CoA inhibits the activity of ATP- and GTP-dependent succinate CoA ligases (2014), J. Inherit. Metab. Dis., 37, 353-357 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.4 additional information not inhibited by valproic acid Homo sapiens
6.2.1.4 valproyl-CoA 25-50% inhibition at 1 mM Homo sapiens
6.2.1.4 ZnCl2 complete inhibition at 1mM Homo sapiens
6.2.1.5 additional information not inhibited by valproic acid Homo sapiens
6.2.1.5 valproyl-CoA 45-55% inhibition at 1 mM Homo sapiens
6.2.1.5 ZnCl2 complete inhibition at 1mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.4 0.63
-
 GTP at pH 8.0 and 37°C Homo sapiens
6.2.1.5 0.25
-
 ATP at pH 8.0 and 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.4 mitochondrion
-
 Homo sapiens 5739
-
6.2.1.5 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.4 GDP + phosphate + succinyl-CoA Homo sapiens
-
 GTP + succinate + CoA
-
 r
6.2.1.4 GTP + succinate + CoA Homo sapiens
-
 GDP + phosphate + succinyl-CoA
-
 r
6.2.1.5 ADP + phosphate + succinyl-CoA Homo sapiens
-
 ATP + succinate + CoA
-
 r
6.2.1.5 ATP + succinate + CoA Homo sapiens
-
 ADP + phosphate + succinyl-CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.4 Homo sapiens
-
-
-
6.2.1.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.4 fibroblast
-
 Homo sapiens
-
6.2.1.5 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.4 GDP + phosphate + succinyl-CoA
-
 Homo sapiens GTP + succinate + CoA
-
 r
6.2.1.4 GTP + succinate + CoA
-
 Homo sapiens GDP + phosphate + succinyl-CoA
-
 r
6.2.1.5 ADP + phosphate + succinyl-CoA
-
 Homo sapiens ATP + succinate + CoA
-
 r
6.2.1.5 ATP + succinate + CoA
-
 Homo sapiens ADP + phosphate + succinyl-CoA
-
 r

Synonyms

EC Number Synonyms Comment Organism
6.2.1.4 G-SUCL
-
 Homo sapiens
6.2.1.4 GTP-dependent succinate:CoA ligase
-
 Homo sapiens
6.2.1.4 GTP-specific succinate:CoA ligase
-
 Homo sapiens
6.2.1.5 A-SUCL
-
 Homo sapiens
6.2.1.5 ATP-dependent succinate:CoA ligase
-
 Homo sapiens
6.2.1.5 ATP-specific succinate:CoA ligase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.4 GTP
-
 Homo sapiens
6.2.1.5 ATP
-
 Homo sapiens