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Literature summary extracted from

  • Rosado, L.A.; Wahni, K.; Degiacomi, G.; Pedre, B.; Young, D.; de la Rubia, A.G.; Boldrin, F.; Martens, E.; Marcos-Pascual, L.; Sancho-Vaello, E.; Albesa-Jove, D.; Provvedi, R.; Martin, C.; Makarov, V.; Versees, W.; Verniest, G.; Guerin, M.E.; Mateos, L.M.; Manganelli, R.; Messens, J.
    The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis (2017), J. Biol. Chem., 292, 13097-13110 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.20.4.3 C19S inactive Mycobacterium tuberculosis
1.20.4.3 C22S the mutant displays a slightly higher reducing activity toward mixed disulfides compared to the wild type enzyme Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.20.4.3 Mycobacterium tuberculosis O53193
-
-
1.20.4.3 Mycobacterium tuberculosis H37Rv O53193
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.20.4.3 additional information the enzyme receives electrons through the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-disulfide mechanism. The enzyme uses a monothiol-disulfide exchange mechanism to reduce S-mycothiolated mixed disulfides and intramolecular disulfides. The enzyme has no oxidase properties Mycobacterium tuberculosis ?
-
 ?
1.20.4.3 additional information the enzyme receives electrons through the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-disulfide mechanism. The enzyme uses a monothiol-disulfide exchange mechanism to reduce S-mycothiolated mixed disulfides and intramolecular disulfides. The enzyme has no oxidase properties Mycobacterium tuberculosis H37Rv ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.20.4.3 ? 2 * 23086, liquid chromatography-mass spectrometry Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
1.20.4.3 Mrx2
-
 Mycobacterium tuberculosis
1.20.4.3 mycoredoxin-2
-
 Mycobacterium tuberculosis
1.20.4.3 mycothiol-dependent reductase
-
 Mycobacterium tuberculosis
1.20.4.3 Rv2466c
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.20.4.3 physiological function the enzyme is essential for bacterial survival under H2O2 stress Mycobacterium tuberculosis