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Literature summary extracted from

  • Greenfield, L.; Richards, M.; Vinogradov, E.; Wakarchuk, W.; Lowary, T.; Whitfield, C.
    Domain organization of the polymerizing mannosyltransferases involved in synthesis of the Escherichia coli O8 and O9a lipopolysaccharide O-antigens (2012), J. Biol. Chem., 287, 38135-38149 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.348 E275A the mutant shows a drastic reduction in activity Escherichia coli
2.4.1.348 E283A the mutant shows about wild type activity Escherichia coli
2.4.1.349 E294A the mutant shows a drastic reduction in activity Escherichia coli
2.4.1.349 E302A the mutant shows about wild type activity Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.371 95500
-
 gel filtration Escherichia coli
2.4.1.371 137000
-
 gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.348 GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol Escherichia coli
-
 GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.348 GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol Escherichia coli CWG636
-
 GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.348 GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol Escherichia coli CWG634
-
 GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.349 GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol Escherichia coli
-
 GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.349 GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol Escherichia coli CWG636
-
 GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.349 GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol Escherichia coli CWG634
-
 GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.348 Escherichia coli
-
-
-
2.4.1.348 Escherichia coli CWG634
-
-
-
2.4.1.349 Escherichia coli
-
-
-
2.4.1.349 Escherichia coli CWG634
-
-
-
2.4.1.371 Escherichia coli
-
 serotype O9a
-
2.4.1.371 Escherichia coli
-
 serotype O8
-
2.4.1.371 Escherichia coli CWG634
-
 serotype O9a
-
2.4.1.371 Escherichia coli CWG636
-
 serotype O8
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.348 GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Escherichia coli GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.348 GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Escherichia coli CWG636 GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.348 GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Escherichia coli CWG634 GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.349 GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Escherichia coli GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.349 GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Escherichia coli CWG636 GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.349 GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Escherichia coli CWG634 GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.4.1.371 2 GDP-alpha-D-mannose + alpha-Manp-(1->2)-alpha-Manp-(1->2)-alpha-Manp-(1->3)-alpha-Manp
-
 Escherichia coli 2 GDP + ?
-
 ?
2.4.1.371 2 GDP-alpha-D-mannose + alpha-Manp-(1->2)-alpha-Manp-(1->2)-alpha-Manp-(1->3)-alpha-Manp
-
 Escherichia coli CWG636 2 GDP + ?
-
 ?
2.4.1.371 2 GDP-alpha-D-mannose + alpha-Manp-(1->2)-alpha-Manp-(1->2)-alpha-Manp-(1->3)-alpha-Manp
-
 Escherichia coli CWG634 2 GDP + ?
-
 ?
2.4.1.371 2 GDP-alpha-D-mannose + alpha-Manp-(1->3)-alpha-Manp-(1->3)-beta-GlcpNAc
-
 Escherichia coli 2 GDP + ?
-
 ?
2.4.1.371 2 GDP-alpha-D-mannose + alpha-Manp-(1->3)-alpha-Manp-(1->3)-beta-GlcpNAc
-
 Escherichia coli CWG636 2 GDP + ?
-
 ?
2.4.1.371 2 GDP-alpha-D-mannose + alpha-Manp-(1->3)-alpha-Manp-(1->3)-beta-GlcpNAc
-
 Escherichia coli CWG634 2 GDP + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.349 ? x * 43900, calculated from amino acid sequence Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.4.1.348 WbdC
-
 Escherichia coli
2.4.1.349 WbdB
-
 Escherichia coli
2.4.1.371 WbdA bifunctional alpha-(1->2)-, alpha-(1->3)-mannosyltransferase Escherichia coli
2.4.1.371 WbdA trifunctional alpha-(1->2)-, alpha-(1->3)-, beta-(1->2)-mannosyltransferase Escherichia coli