Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liu, Y.C.; Lee, M.R.; Chen, C.J.; Lin, Y.C.; Ho, H.C.
    Purification of Cu/Zn superoxide dismutase from Piper betle leaf and its characterization in the oral cavity (2015), J. Agric. Food Chem., 63, 2225-2232 .
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Cu2+ a Cu/Zn SOD Piper betle
1.15.1.1 Zn2+ a Cu/Zn SOD Piper betle

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 2 superoxide + 2 H+ Piper betle
-
 O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Piper betle
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.15.1.1 native enzyme from leaves to apparent homogeneity Piper betle

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 leaf
-
 Piper betle
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 2 superoxide + 2 H+
-
 Piper betle O2 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.15.1.1 dimer 2 * 15700, SDS-PAGE Piper betle
1.15.1.1 monomer 1 * 15700, SDS-PAGE Piper betle
1.15.1.1 More the purified SOD appears to be monomeric and converts to its dimeric form with increased enzymatic activity in betel nut oral extract. This irreversible conversion is mainly induced by slaked lime, resulting from the increase in pH of the oral cavity. Oral extract from chewing areca nut alone also induces SOD dimerization due to the presence of arginine Piper betle

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 Cu/Zn SOD
-
 Piper betle
1.15.1.1 Cu/Zn superoxide dismutase
-
 Piper betle
1.15.1.1 SOD
-
 Piper betle

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.15.1.1 7
-
 assay at Piper betle

General Information

EC Number General Information Comment Organism
1.15.1.1 physiological function the enhanced activity of the SOD dimer in betel nut oral extract is responsible for the continuous production of hydrogen peroxide in the oral cavity. SOD may contribute to oral carcinogenesis through the continuous formation of hydrogen peroxide in the oral cavity, in spite of its protective role against cancer in vivo Piper betle