BRENDA - Enzyme Database

Insulin receptor-mediated nutritional signalling regulates juvenile hormone biosynthesis and vitellogenin production in the German cockroach

Abrisqueta, M.; Sueren-Castillo, S.; Maestro, J.L.; Insect Biochem. Mol. Biol. 49, 14-23 (2014)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Cloned (Commentary)
Organism
1.14.13.202
gene CYP15A1, RT-PCR enzyme expression analysis
Blattella germanica
1.14.14.127
gene CYP15A1, RT-PCR enzyme expression analysis
Blattella germanica
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.14.13.202
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
Blattella germanica
-
juvenile hormone III + NADP+ + H2O
-
-
?
1.14.14.127
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
Blattella germanica
-
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.14.13.202
Blattella germanica
D6CJJ9
-
-
1.14.14.127
Blattella germanica
D6CJJ9
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.13.202
corpus allatum
-
Blattella germanica
-
1.14.14.127
corpus allatum
-
Blattella germanica
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1.14.13.202
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
-
745073
Blattella germanica
juvenile hormone III + NADP+ + H2O
-
-
-
?
1.14.14.127
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
745073
Blattella germanica
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
1.14.13.202
CYP15A1
-
Blattella germanica
1.14.13.202
CYP15A1 protein
-
Blattella germanica
1.14.14.127
CYP15A1
-
Blattella germanica
1.14.14.127
CYP15A1 protein
-
Blattella germanica
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.14.13.202
cytochrome P450
-
Blattella germanica
1.14.13.202
NADPH
-
Blattella germanica
1.14.14.127
cytochrome P450
-
Blattella germanica
1.14.14.127
NADPH-hemoprotein reductase
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._
Blattella germanica
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.14.13.202
gene CYP15A1, RT-PCR enzyme expression analysis
Blattella germanica
1.14.14.127
gene CYP15A1, RT-PCR enzyme expression analysis
Blattella germanica
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.14.13.202
cytochrome P450
-
Blattella germanica
1.14.13.202
NADPH
-
Blattella germanica
1.14.14.127
cytochrome P450
-
Blattella germanica
1.14.14.127
NADPH-hemoprotein reductase
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._
Blattella germanica
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.14.13.202
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
Blattella germanica
-
juvenile hormone III + NADP+ + H2O
-
-
?
1.14.14.127
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
Blattella germanica
-
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.13.202
corpus allatum
-
Blattella germanica
-
1.14.14.127
corpus allatum
-
Blattella germanica
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1.14.13.202
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
-
745073
Blattella germanica
juvenile hormone III + NADP+ + H2O
-
-
-
?
1.14.14.127
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
745073
Blattella germanica
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
1.14.13.202
Blattella germanica
starving reduces the enzyme expression
down
1.14.14.127
Blattella germanica
starving reduces the enzyme expression
down
General Information
EC Number
General Information
Commentary
Organism
1.14.13.202
malfunction
BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview
Blattella germanica
1.14.13.202
metabolism
the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway
Blattella germanica
1.14.14.127
malfunction
BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview
Blattella germanica
1.14.14.127
metabolism
the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway
Blattella germanica
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.14.13.202
malfunction
BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview
Blattella germanica
1.14.13.202
metabolism
the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway
Blattella germanica
1.14.14.127
malfunction
BgInR knockdown leads to a severe inhibition of juvenile hormone synthesis in adult female corpora allata, with a concomitant reduction of mRNA levels corresponding to 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase-1, HMG-CoA synthase-2, HMG-CoA reductase and methyl farnesoate epoxidase, phenotype, overview
Blattella germanica
1.14.14.127
metabolism
the enzyme is important in the biosynthesis and regulation of juvenile hormone in the JH specific pathway
Blattella germanica
Expression (protein specific)
EC Number
Organism
Commentary
Expression
1.14.13.202
Blattella germanica
starving reduces the enzyme expression
down
1.14.14.127
Blattella germanica
starving reduces the enzyme expression
down