BRENDA - Enzyme Database

Gene expression dynamics in major endocrine regulatory pathways along the transition from solitary to social life in a bumblebee, Bombus terrestris

Jedlicka, P.; Ernst, U.; Votavova, A.; Hanus, R.; Valterova, I.; Front. Physiol. 7, 574 (2016)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Cloned (Commentary)
Organism
1.14.13.202
gene MFE, quantitative RT-PCR enzyme expression analysis
Bombus terrestris terrestris
1.14.14.127
gene MFE, quantitative RT-PCR enzyme expression analysis
Bombus terrestris terrestris
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.14.13.202
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
Bombus terrestris terrestris
-
juvenile hormone III + NADP+ + H2O
-
-
?
1.14.14.127
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
Bombus terrestris terrestris
-
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.14.13.202
Bombus terrestris terrestris
-
-
-
1.14.14.127
Bombus terrestris terrestris
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.13.202
brain
-
Bombus terrestris terrestris
-
1.14.13.202
crop
-
Bombus terrestris terrestris
-
1.14.13.202
fat body
-
Bombus terrestris terrestris
-
1.14.13.202
flight muscle
-
Bombus terrestris terrestris
-
1.14.13.202
gonad
-
Bombus terrestris terrestris
-
1.14.13.202
labial gland
-
Bombus terrestris terrestris
-
1.14.13.202
additional information
expression analysis of tissue-specific relative expression levels methyl farnesoate epoxidase (MFE) across castes of Bombus terrestris, overview
Bombus terrestris terrestris
-
1.14.13.202
ovary
of workers and reproducing queens, high MFE expression in ovaries of bumblebee females
Bombus terrestris terrestris
-
1.14.13.202
rectum
-
Bombus terrestris terrestris
-
1.14.13.202
ventriculus
-
Bombus terrestris terrestris
-
1.14.14.127
brain
-
Bombus terrestris terrestris
-
1.14.14.127
crop
-
Bombus terrestris terrestris
-
1.14.14.127
fat body
-
Bombus terrestris terrestris
-
1.14.14.127
flight muscle
-
Bombus terrestris terrestris
-
1.14.14.127
gonad
-
Bombus terrestris terrestris
-
1.14.14.127
labial gland
-
Bombus terrestris terrestris
-
1.14.14.127
additional information
expression analysis of tissue-specific relative expression levels methyl farnesoate epoxidase (MFE) across castes of Bombus terrestris, overview
Bombus terrestris terrestris
-
1.14.14.127
ovary
of workers and reproducing queens, high MFE expression in ovaries of bumblebee females
Bombus terrestris terrestris
-
1.14.14.127
rectum
-
Bombus terrestris terrestris
-
1.14.14.127
ventriculus
-
Bombus terrestris terrestris
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1.14.13.202
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
-
744987
Bombus terrestris terrestris
juvenile hormone III + NADP+ + H2O
-
-
-
?
1.14.14.127
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
744987
Bombus terrestris terrestris
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
1.14.13.202
MFE
-
Bombus terrestris terrestris
1.14.14.127
MFE
-
Bombus terrestris terrestris
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.14.13.202
NADPH
-
Bombus terrestris terrestris
1.14.14.127
NADPH-hemoprotein reductase
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._
Bombus terrestris terrestris
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.14.13.202
gene MFE, quantitative RT-PCR enzyme expression analysis
Bombus terrestris terrestris
1.14.14.127
gene MFE, quantitative RT-PCR enzyme expression analysis
Bombus terrestris terrestris
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.14.13.202
NADPH
-
Bombus terrestris terrestris
1.14.14.127
NADPH-hemoprotein reductase
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._
Bombus terrestris terrestris
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.14.13.202
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
Bombus terrestris terrestris
-
juvenile hormone III + NADP+ + H2O
-
-
?
1.14.14.127
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
Bombus terrestris terrestris
-
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.13.202
brain
-
Bombus terrestris terrestris
-
1.14.13.202
crop
-
Bombus terrestris terrestris
-
1.14.13.202
fat body
-
Bombus terrestris terrestris
-
1.14.13.202
flight muscle
-
Bombus terrestris terrestris
-
1.14.13.202
gonad
-
Bombus terrestris terrestris
-
1.14.13.202
labial gland
-
Bombus terrestris terrestris
-
1.14.13.202
additional information
expression analysis of tissue-specific relative expression levels methyl farnesoate epoxidase (MFE) across castes of Bombus terrestris, overview
Bombus terrestris terrestris
-
1.14.13.202
ovary
of workers and reproducing queens, high MFE expression in ovaries of bumblebee females
Bombus terrestris terrestris
-
1.14.13.202
rectum
-
Bombus terrestris terrestris
-
1.14.13.202
ventriculus
-
Bombus terrestris terrestris
-
1.14.14.127
brain
-
Bombus terrestris terrestris
-
1.14.14.127
crop
-
Bombus terrestris terrestris
-
1.14.14.127
fat body
-
Bombus terrestris terrestris
-
1.14.14.127
flight muscle
-
Bombus terrestris terrestris
-
1.14.14.127
gonad
-
Bombus terrestris terrestris
-
1.14.14.127
labial gland
-
Bombus terrestris terrestris
-
1.14.14.127
additional information
expression analysis of tissue-specific relative expression levels methyl farnesoate epoxidase (MFE) across castes of Bombus terrestris, overview
Bombus terrestris terrestris
-
1.14.14.127
ovary
of workers and reproducing queens, high MFE expression in ovaries of bumblebee females
Bombus terrestris terrestris
-
1.14.14.127
rectum
-
Bombus terrestris terrestris
-
1.14.14.127
ventriculus
-
Bombus terrestris terrestris
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1.14.13.202
methyl (2E,6E)-farnesoate + NADPH + H+ + O2
-
744987
Bombus terrestris terrestris
juvenile hormone III + NADP+ + H2O
-
-
-
?
1.14.14.127
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
744987
Bombus terrestris terrestris
juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
1.14.13.202
metabolism
the enzyme catalyzes the final step of juvenile hormone III biosynthesis
Bombus terrestris terrestris
1.14.13.202
physiological function
the methyl farnesoate epoxidase gene (MFE) is an indicator of juvenile hormone production. Virgin queens are distinguished by higher expression of forkhead box protein O and downregulated insulin-like peptides and juvenile hormone signaling, indicated by low expression of methyl farnesoate epoxidase (MFE) and transcription factor Krüppel homolog 1 (Kr-h1), while reproducing queens reveal an upregulation of MFE and vitellogenin together with insulin signaling. Workers exhibit an expression pattern of MFE and vitellogenin similar to that of reproducing queens. Males aere characterized by high Kr-h1expression and low vitellogenin level
Bombus terrestris terrestris
1.14.14.127
metabolism
the enzyme catalyzes the final step of juvenile hormone III biosynthesis
Bombus terrestris terrestris
1.14.14.127
physiological function
the methyl farnesoate epoxidase gene (MFE) is an indicator of juvenile hormone production. Virgin queens are distinguished by higher expression of forkhead box protein O and downregulated insulin-like peptides and juvenile hormone signaling, indicated by low expression of methyl farnesoate epoxidase (MFE) and transcription factor Krüppel homolog 1 (Kr-h1), while reproducing queens reveal an upregulation of MFE and vitellogenin together with insulin signaling. Workers exhibit an expression pattern of MFE and vitellogenin similar to that of reproducing queens. Males aere characterized by high Kr-h1expression and low vitellogenin level
Bombus terrestris terrestris
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.14.13.202
metabolism
the enzyme catalyzes the final step of juvenile hormone III biosynthesis
Bombus terrestris terrestris
1.14.13.202
physiological function
the methyl farnesoate epoxidase gene (MFE) is an indicator of juvenile hormone production. Virgin queens are distinguished by higher expression of forkhead box protein O and downregulated insulin-like peptides and juvenile hormone signaling, indicated by low expression of methyl farnesoate epoxidase (MFE) and transcription factor Krüppel homolog 1 (Kr-h1), while reproducing queens reveal an upregulation of MFE and vitellogenin together with insulin signaling. Workers exhibit an expression pattern of MFE and vitellogenin similar to that of reproducing queens. Males aere characterized by high Kr-h1expression and low vitellogenin level
Bombus terrestris terrestris
1.14.14.127
metabolism
the enzyme catalyzes the final step of juvenile hormone III biosynthesis
Bombus terrestris terrestris
1.14.14.127
physiological function
the methyl farnesoate epoxidase gene (MFE) is an indicator of juvenile hormone production. Virgin queens are distinguished by higher expression of forkhead box protein O and downregulated insulin-like peptides and juvenile hormone signaling, indicated by low expression of methyl farnesoate epoxidase (MFE) and transcription factor Krüppel homolog 1 (Kr-h1), while reproducing queens reveal an upregulation of MFE and vitellogenin together with insulin signaling. Workers exhibit an expression pattern of MFE and vitellogenin similar to that of reproducing queens. Males aere characterized by high Kr-h1expression and low vitellogenin level
Bombus terrestris terrestris