Literature summary extracted from

Enright, J.M.; Toomey, M.B.; Sato, S.Y.; Temple, S.E.; Allen, J.R.; Fujiwara, R.; Kramlinger, V.M.; Nagy, L.D.; Johnson, K.M.; Xiao, Y.; How, M.J.; Johnson, S.L.; Roberts, N.W.; Kefalov, V.J.; Guengerich, F.P.; Corbo, J.C.
Cyp27c1 red-shifts the spectral sensitivity of photoreceptors by converting vitamin A1 into A2 (2015), Curr. Biol., 25, 3048-3057 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.19.53	Danio rerio	A8WGA0	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.19.53	all-trans-retinal + 2 reduced adrenodoxin + 2 H+ + O2	-	Danio rerio	all-trans-3,4-didehydroretinal + 2 oxidized adrenodoxin + 2 H2O	-	?
1.14.19.53	all-trans-retinoic acid + 2 reduced adrenodoxin + 2 H+ + O2	-	Danio rerio	all-trans-3,4-didehydroretinoic acid + 2 oxidized adrenodoxin + 2 H2O	-	?
1.14.19.53	all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2	-	Danio rerio	all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.19.53	cytochrome P450	-	Danio rerio

General Information

EC Number	General Information	Comment	Organism
1.14.19.53	physiological function	knockout of Cyp27c1 in zebrafish abrogates production of vitamin A2, eliminates the animal's ability to red-shift its photoreceptor spectral sensitivity, and reduces its ability to see and respond to near-infrared light	Danio rerio

kcat/KM [mM/s]

EC Number	kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
1.14.19.53	800	-	all-trans-retinal	37°C, pH not specified in the publication	Danio rerio
1.14.19.53	800	-	all-trans-retinoic acid	37°C, pH not specified in the publication	Danio rerio
1.14.19.53	1900	-	all-trans-retinol	37°C, pH not specified in the publication	Danio rerio

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Release 2023.1 (January 2023)