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Literature summary extracted from

  • Rezapour-Firouzi, S.; Arefhosseini, S.R.; Ebrahimi-Mamaghani, M.; Baradaran, B.; Sadeghihokmabad, E.; Mostafaei, S.; Torbati, M.; Chehreh, M.
    Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients (2015), Complement. Ther. Med., 23, 652-657 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.3 additional information aging, diabetes, viral infection, high alcohol intake, high level cholesterol, high blood pressure, radiation, stress-related hormones, deficiencies of zinc, magnesium, biotin, the vitamins C, B6, and B3, and excessive level of trans fatty acid reduce the enzyme activity in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.3 alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Homo sapiens
-
 stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.3 linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Homo sapiens
-
 gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.3 Homo sapiens O95864
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.3 alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.3 linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.3 D6 desaturase
-
 Homo sapiens
1.14.19.3 D6D
-
 Homo sapiens
1.14.19.3 DELTA-6-desaturase
-
 Homo sapiens
1.14.19.3 FADS2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.19.3 metabolism the enzyme follows the omega3 and omega6 pathways. Regulation of surface-membrane enzymes such as delta-6-desaturase and secretory phospholipase A2 by hemp seed and evening primrose oils as well as hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS) patients having beneficial effects in improving clinical symptoms and signs in the patients, possible mechanisms, overview Homo sapiens
1.14.19.3 physiological function regulation of surface-membrane enzymes such as delta-6-desaturase and secretory phospholipase A2 by hemp seed and evening primrose oils as well as hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS) patients having beneficial effects in improving clinical symptoms and signs in the patients, possible mechanisms, overview. FADS2 enzyme catalyzes the rate-limiting step in the biosynthetic pathways for polyunsaturated fatty acids that are incorporated into cell membranes, thereby affecting permeability, and functional propertiesof cells. There isa correlation between multile sclerosis and a rapid fall of FADS6 enzyme activity Homo sapiens