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Literature summary extracted from

  • Guerra, F.; Wang, K.; Li, J.; Wang, W.; Liu, Y.; Amin, S.; Oldfield, E.
    Inhibition of the 4Fe-4S proteins IspG and IspH An EPR, ENDOR and HYSCORE investigation (2014), Chem. Sci., 5, 1642-1649 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.7.3 (2Z)-3-methyl-4-sulfanylbut-2-en-1-yl trihydrogen diphosphate
-
 Escherichia coli
1.17.7.3 (2Z)-4-amino-3-methylbut-2-en-1-yl trihydrogen diphosphate
-
 Escherichia coli
1.17.7.3 but-3-yn-1-yl trihydrogen diphosphate
-
 Escherichia coli
1.17.7.3 prop-2-yn-1-yl trihydrogen diphosphate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.7.3 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin Escherichia coli
-
 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.7.3 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.7.3 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin
-
 Escherichia coli 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.7.3 2-C-methyl-D-erythritol-2,4-cyclodiphosphate reductase
-
 Escherichia coli
1.17.7.3 IspG
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.7.3 [4Fe-4S]-center
-
 Escherichia coli