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Literature summary extracted from

  • Kim, S.; Park, J.; Kim, S.; Kim, J.; Roh, K.; Kim, H.; Lee, K.; Kim, J.
    Functional characterization of polyunsaturated fatty acid delta 6-desaturase and elongase genes from the black seabream (Acanthopagrus schlegelii) (2014), Cell Biochem. Biophys., 68, 335-346 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.3 gene D6DES, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, functional expression in Saccharomyces cerevisiae strain INVSc1 producing gamma-linolenic acid and stearidonic acid at conversion rates of 26.3-35.6% from exogenous linoleic acid and alpha-linolenic acid substrates, respectively. Fatty acid profiles of GC analysis from transgenic Saccharomyces cerevisiae strain INVSc1, overview Acanthopagrus schlegelii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.3 alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Acanthopagrus schlegelii
-
 stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.3 linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Acanthopagrus schlegelii
-
 gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.3 Acanthopagrus schlegelii A0A1S5R926
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.3 alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Acanthopagrus schlegelii stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.3 linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Acanthopagrus schlegelii gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.3 AsD6DES
-
 Acanthopagrus schlegelii
1.14.19.3 D6Des
-
 Acanthopagrus schlegelii
1.14.19.3 fatty acid DELTA 6-desaturase
-
 Acanthopagrus schlegelii

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.3 cytochrome b5 the enzyme contains a cytochrome b5 domain Acanthopagrus schlegelii

General Information

EC Number General Information Comment Organism
1.14.19.3 evolution phylogenetic tree of AsD6DES and delta 6- and delta 5-desaturases Acanthopagrus schlegelii
1.14.19.3 metabolism fatty acid delta 6-desaturase (D6DES) and elongases are key enzymes in the synthesis of polyunsaturated fatty acids (PUFAs) including arachidonic acid (ARA) and eicosapentaenoic acid (EPA) from microorganisms to higher animals. Proposed pathways of polyunsaturated fatty acid biosynthesis from a-linolenic acid and linoleic acid in Acanthopagrus schlegelii, overview Acanthopagrus schlegelii