EC Number | Cloned (Comment) | Organism |
---|---|---|
1.15.1.1 | gene sodC, DNA and amino acid sequence determination and analysis, recombinant expression of His-tagged enzyme in Escherichia coli, recombinant overexpression of the enzyme from AS454(pREB102) in an Escherichia coli sodC mutant leads to complementation restoring resistance to H2O2 killing to wild-type levels | Coxiella burnetii |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.15.1.1 | diethyldithiocarbamate | a specific inhibitor for CuZn-SODs | Coxiella burnetii | |
1.15.1.1 | H2O2 | inhibition at 5 mM | Coxiella burnetii |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.15.1.1 | extracellular | the enzyme is secreted | Coxiella burnetii | - |
- |
1.15.1.1 | periplasm | - |
Coxiella burnetii | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.15.1.1 | Cu2+ | a CuZn-superoxide dismutase | Coxiella burnetii | |
1.15.1.1 | Zn2+ | a CuZn-superoxide dismutase | Coxiella burnetii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.15.1.1 | 2 superoxide + 2 H+ | Coxiella burnetii | - |
O2 + H2O2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.15.1.1 | Coxiella burnetii | Q83AQ8 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.15.1.1 | recombinant His-tagged enzyme from Escherichia coli | Coxiella burnetii |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.15.1.1 | 2 superoxide + 2 H+ | - |
Coxiella burnetii | O2 + H2O2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.15.1.1 | ? | x * 18000, recombinant His-tagged enzyme, SDS-PAGE | Coxiella burnetii |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.15.1.1 | copper-zinc superoxide dismutase | - |
Coxiella burnetii |
1.15.1.1 | Cu/Zn superoxide dismutase | - |
Coxiella burnetii |
1.15.1.1 | Cu/ZnSOD | - |
Coxiella burnetii |
1.15.1.1 | SOD | - |
Coxiella burnetii |
1.15.1.1 | SodC | - |
Coxiella burnetii |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.15.1.1 | 5 | 9 | active at | Coxiella burnetii |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.15.1.1 | physiological function | the ZnSOD is a potentially important virulence factor | Coxiella burnetii |