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Literature summary extracted from

  • Abbas, S.; Mok, K.; Rashid, N.; Xie, Y.; Ruether, M.; OBrien, J.; Akhtar, M.
    NMR studies on mechanism of isomerisation of fructose 6-phosphate to glucose 6-phosphate catalysed by phosphoglucose isomerase from Thermococcus kodakarensis (2016), Bioorg. Chem., 66, 41-45 .
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.3.1.9 Zn2+ meta-dependent phosphoglucose isomerase which requires Zn2+ for its activity. The presence of metal electrophile to activate the carbonyl group is required not only for the hydride shift mechanism but also for the operation of an enediol process Thermococcus kodakarensis
5.3.1.9 Zn2+ the presence of a metal electrophile to activate the carbonyl group is required not only for the hydride shift mechanism but also for the operation of an enediol process Thermococcus kodakarensis

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.9 Thermococcus kodakarensis
-
-
-
5.3.1.9 Thermococcus kodakarensis Q5JE38
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.9 D-fructose 6-phosphate
-
 Thermococcus kodakarensis D-glucose 6-phosphate
-
 ?
5.3.1.9 D-fructose 6-phosphate the isomerization occurrs by a cis-enediol intermediate involving C-1 pro-R hydrogen of D-fructose 6-phosphate. The presence of metal electrophile to activate the carbonyl group is required not only for the hydride shift mechanism but also for the operation of an enediol process Thermococcus kodakarensis D-glucose 6-phosphate
-
 r
5.3.1.9 additional information the isomerization occurs by a cis-enediol intermediate involving the C-1 pro-R hydrogen atom of fructose 6-phosphate. The presence of a metal electrophile to activate the carbonyl group is required not only for the hydride shift mechanism but also for the operation of an enediol process Thermococcus kodakarensis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.1.9 PGI
-
 Thermococcus kodakarensis
5.3.1.9 Phosphoglucose isomerase
-
 Thermococcus kodakarensis
5.3.1.9 TK1111 locus name Thermococcus kodakarensis