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Literature summary extracted from
- The amino acid specificity for activation of phenylalanine hydroxylase matches the specificity for stabilization of regulatory domain dimers (2015), Biochemistry, 54, 5167-5174 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.1 | (S)-2-amino-3-phenyl-1-propanol | 6.5fold activation at 10 mM | Rattus norvegicus |  |
| 1.14.16.1 | 3-Phenylpropionate | 1.8fold activation at 50 mM | Rattus norvegicus | |
| 1.14.16.1 | D-phenylalanine | 7.1fold activation at 10 mM | Rattus norvegicus | |
| 1.14.16.1 | L-4-aminophenylalanine | 3.2fold activation at 10 mM | Rattus norvegicus | |
| 1.14.16.1 | L-isoleucine | 1.5fold activation at 50 mM | Rattus norvegicus | |
| 1.14.16.1 | L-leucine | 2.2fold activation at 50 mM | Rattus norvegicus | |
| 1.14.16.1 | L-methionine | 5.8fold activation at 50 mM | Rattus norvegicus | |
| 1.14.16.1 | L-norleucine | 6.6fold activation at 50 mM | Rattus norvegicus | |
| 1.14.16.1 | L-phenylalanine | 6fold activation at 1 mM | Rattus norvegicus | |
| 1.14.16.1 | additional information | not significantly activated by L-valine, L-alanine, and L-serine | Rattus norvegicus |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.16.1 | - |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.1 | L-phenylalanine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.1 | Rattus norvegicus | P04176 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.16.1 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.16.1 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.1 | L-phenylalanine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.16.1 | PheH | - |
Rattus norvegicus |
| 1.14.16.1 | phenylalanine hydroxylase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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