EC Number | Cloned (Comment) | Organism |
---|---|---|
1.17.1.8 | expression in Escherichia coli BL21 (DE3) cells | Vitis vinifera |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.17.1.8 | sitting-drop vapour-diffusion method | Selaginella moellendorffii |
1.17.1.8 | sitting-drop vapour-diffusion method | Neisseria meningitidis |
1.17.1.8 | vapour-diffusion method | Arabidopsis thaliana |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | dihydrodipicolinate reductase enzymes from plants are much more prone to substrate inhibition than the bacterial enzymes, which appears to be a consequence of increased flexibility of the substrate-binding loop and higher affinity for the nucleotide substrate | Arabidopsis thaliana | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | dihydrodipicolinate reductase enzymes from plants are much more prone to substrate inhibition than the bacterial enzymes, which appears to be a consequence of increased flexibility of the substrate-binding loop and higher affinity for the nucleotide substrate | Neisseria meningitidis | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | dihydrodipicolinate reductase enzymes from plants are much more prone to substrate inhibition than the bacterial enzymes, which appears to be a consequence of increased flexibility of the substrate-binding loop and higher affinity for the nucleotide substrate | Selaginella moellendorffii | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | dihydrodipicolinate reductase enzymes from plants are much more prone to substrate inhibition than the bacterial enzymes, which appears to be a consequence of increased flexibility of the substrate-binding loop and higher affinity for the nucleotide substrate | Vitis vinifera |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.1.8 | 0.0005 | - |
NADH | pH 8.0, 25°C | Neisseria meningitidis | |
1.17.1.8 | 0.0014 | - |
NADH | pH 8.0, 25°C | Selaginella moellendorffii | |
1.17.1.8 | 0.0031 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Vitis vinifera | |
1.17.1.8 | 0.0047 | - |
NADH | pH 8.0, 25°C | Vitis vinifera | |
1.17.1.8 | 0.0068 | - |
NADPH | pH 8.0, 25°C | Selaginella moellendorffii | |
1.17.1.8 | 0.0092 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADPH | Vitis vinifera | |
1.17.1.8 | 0.012 | - |
NADPH | pH 8.0, 25°C | Neisseria meningitidis | |
1.17.1.8 | 0.012 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Selaginella moellendorffii | |
1.17.1.8 | 0.013 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Neisseria meningitidis | |
1.17.1.8 | 0.016 | - |
NADPH | pH 8.0, 25°C | Vitis vinifera | |
1.17.1.8 | 0.058 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADPH | Selaginella moellendorffii | |
1.17.1.8 | 0.085 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADPH | Neisseria meningitidis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.17.1.8 | 62900 | - |
calculated | Vitis vinifera |
1.17.1.8 | 64200 | - |
calculated | Selaginella moellendorffii |
1.17.1.8 | 113000 | - |
calculated | Neisseria meningitidis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | Neisseria meningitidis | - |
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | Selaginella moellendorffii | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | Arabidopsis thaliana | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | Vitis vinifera | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.17.1.8 | Arabidopsis thaliana | Q8LB01 | - |
- |
1.17.1.8 | Neisseria meningitidis | Q9K1F1 | - |
- |
1.17.1.8 | Selaginella moellendorffii | D8R6G2 | - |
- |
1.17.1.8 | Vitis vinifera | F6HB41 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | - |
Arabidopsis thaliana | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | - |
Neisseria meningitidis | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | Selaginella moellendorffii | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | Arabidopsis thaliana | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | Vitis vinifera | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ | - |
Selaginella moellendorffii | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ | - |
Vitis vinifera | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ | - |
Neisseria meningitidis | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ | - |
Selaginella moellendorffii | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ | - |
Vitis vinifera | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O | - |
? | |
1.17.1.8 | (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ | - |
Neisseria meningitidis | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.17.1.8 | dimer | the dimer forms through the intra-strand interface. Unique secondary features in plant enzymes block tetramer assembly | Selaginella moellendorffii |
1.17.1.8 | dimer | the dimer forms through the intra-strand interface. Unique secondary features in plant enzymes block tetramer assembly | Arabidopsis thaliana |
1.17.1.8 | dimer | the dimer forms through the intra-strand interface. Unique secondary features in plant enzymes block tetramer assembly | Vitis vinifera |
1.17.1.8 | tetramer | - |
Neisseria meningitidis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.17.1.8 | DapB | - |
Neisseria meningitidis |
1.17.1.8 | DHDPR | - |
Selaginella moellendorffii |
1.17.1.8 | DHDPR | - |
Arabidopsis thaliana |
1.17.1.8 | DHDPR | - |
Vitis vinifera |
1.17.1.8 | DHDPR | - |
Neisseria meningitidis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.17.1.8 | 25 | - |
assay at | Selaginella moellendorffii |
1.17.1.8 | 25 | - |
assay at | Arabidopsis thaliana |
1.17.1.8 | 25 | - |
assay at | Vitis vinifera |
1.17.1.8 | 25 | - |
assay at | Neisseria meningitidis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.1.8 | 14 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Vitis vinifera | |
1.17.1.8 | 21 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADPH | Vitis vinifera | |
1.17.1.8 | 43 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADPH | Neisseria meningitidis | |
1.17.1.8 | 49 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Selaginella moellendorffii | |
1.17.1.8 | 63 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADPH | Selaginella moellendorffii | |
1.17.1.8 | 77 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Neisseria meningitidis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.17.1.8 | 8 | - |
assay at | Selaginella moellendorffii |
1.17.1.8 | 8 | - |
assay at | Arabidopsis thaliana |
1.17.1.8 | 8 | - |
assay at | Vitis vinifera |
1.17.1.8 | 8 | - |
assay at | Neisseria meningitidis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.17.1.8 | NADH | - |
Selaginella moellendorffii | |
1.17.1.8 | NADH | - |
Vitis vinifera | |
1.17.1.8 | NADPH | - |
Selaginella moellendorffii | |
1.17.1.8 | NADPH | - |
Vitis vinifera |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.17.1.8 | 0.032 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Selaginella moellendorffii | |
1.17.1.8 | 0.76 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Vitis vinifera | |
1.17.1.8 | 1.3 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADPH | Selaginella moellendorffii | |
1.17.1.8 | 1.8 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADPH | Vitis vinifera | |
1.17.1.8 | 5.5 | - |
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate | pH 8.0, 25°C, cofactor: NADH | Neisseria meningitidis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.17.1.8 | metabolism | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | Selaginella moellendorffii |
1.17.1.8 | metabolism | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | Arabidopsis thaliana |
1.17.1.8 | metabolism | the enzyme catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants | Vitis vinifera |