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Literature summary extracted from
- Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with L-proline (2017), Biochem. Biophys. Res. Commun., 488, 393-399 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.1.1.15 | 3-(3,3-dimethylbutanamido)-N-[(naphthalen-1-yl)methyl]pyrazine-2-carboxamide | - |
Homo sapiens |  |
| 6.1.1.15 | 3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide | - |
Homo sapiens | |
| 6.1.1.15 | halofuginone | - |
Homo sapiens | |
| 6.1.1.15 | N-[(4-chlorophenyl)methyl]-3-[(cyclohexanecarbonyl)amino]pyrazine-2-carboxamide | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.1.1.15 | ATP + L-proline + tRNAPro | Homo sapiens | - |
AMP + diphosphate + L-prolyl-tRNAPro | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.1.1.15 | Homo sapiens | P07814 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.1.1.15 | ATP + L-proline + tRNAPro | - |
Homo sapiens | AMP + diphosphate + L-prolyl-tRNAPro | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 6.1.1.15 | Prolyl-tRNA synthetase | - |
Homo sapiens |
| 6.1.1.15 | PRS | - |
Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 6.1.1.15 | 53.7 | - |
melting temperature | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.1.1.15 | ATP | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 6.1.1.15 | 0.012 | - |
at pH 7.5 and 25°C | Homo sapiens | 3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide | |
| 6.1.1.15 | 0.11 | - |
at pH 7.5 and 25°C | Homo sapiens | 3-(3,3-dimethylbutanamido)-N-[(naphthalen-1-yl)methyl]pyrazine-2-carboxamide | |
| 6.1.1.15 | 0.25 | - |
at pH 7.5 and 25°C | Homo sapiens | N-[(4-chlorophenyl)methyl]-3-[(cyclohexanecarbonyl)amino]pyrazine-2-carboxamide | |
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Release 2023.1 (January 2023)
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