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Literature summary extracted from

  • Shokri, E.; Nematzadeh, G.; Zolala, J.; Nasiri, N.; Kazemi-Tabar, S.; Hosseinpour-Azad, N.
    Delta-6 desaturase makes a different fatty acid profile of seed oil in Iranian borage (Echium amoenum Fisch. and Mey.) (2014), Acta Physiol. Plant., 36, 2413-2418 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.3 gene d6-des, DNA and amino acid sequence determination and analysis, sequence comparisons Echium amoenum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.3 alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Echium amoenum
-
 stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.3 linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Echium amoenum
-
 gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.3 Echium amoenum D2KP14
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.3 seed
-
 Echium amoenum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.3 alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Echium amoenum stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.3 linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Echium amoenum gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.19.3 More secondary structure of the enzyme deduced from its primary structure using computational simulation Echium amoenum

Synonyms

EC Number Synonyms Comment Organism
1.14.19.3 d6-des
-
 Echium amoenum
1.14.19.3 D6Des
-
 Echium amoenum
1.14.19.3 DELTA-6 desaturase
-
 Echium amoenum
1.14.19.3 EaD6DES
-
 Echium amoenum

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.3 cytochrome b5 the enzyme contains a cytochrome b5 domain and three conserved histidine-rich motifs Echium amoenum

General Information

EC Number General Information Comment Organism
1.14.19.3 evolution weak activity and different secondary structure of delta-6 desaturase (D6DES) in Echium amoenum compared with D6DESs of other species Echium amoenum
1.14.19.3 additional information analysis of functional sites and substrate binding motifs of D6DES enzyme, overview Echium amoenum
1.14.19.3 physiological function D6DES enzyme is responsible for converting linoleic acid and alpha-linolenic acid to gamma-linolenoic acid and stearidonic acid Echium amoenum