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Literature summary extracted from

  • Liu, Q.; Chen, L.; Zhang, Z.; Du, B.; Xiao, Y.; Yang, K.; Gong, L.; Wu, L.; Li, X.; He, Y.
    pH-Dependent enantioselectivity of D-amino acid oxidase in aqueous solution (2017), Sci. Rep., 7, 2994 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.3 0.33
-
 D-Pro at pH 8.0 and 37°C Sus scrofa
1.4.3.3 0.38
-
 D-Pro at pH 7.5 and 37°C Sus scrofa
1.4.3.3 0.85
-
 D-Pro at pH 8.5 and 37°C Sus scrofa
1.4.3.3 20
-
 L-Pro at pH 8.0 and 37°C Sus scrofa
1.4.3.3 30.5
-
 D-Ala at pH 7.0 and 37°C Sus scrofa
1.4.3.3 38.2
-
 D-Ala at pH 9.8 and 37°C Sus scrofa
1.4.3.3 43
-
 D-Asp at pH 8.0 and 37°C Sus scrofa
1.4.3.3 43.11
-
 L-Ala at pH 9.8 and 37°C Sus scrofa
1.4.3.3 45
-
 L-Asp at pH 8.0 and 37°C Sus scrofa
1.4.3.3 252
-
 L-Pro at pH 7.5 and 37°C Sus scrofa
1.4.3.3 362
-
 L-Ala at pH 7.0 and 37°C Sus scrofa
1.4.3.3 1800
-
 L-Pro at pH 8.5 and 37°C Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-Ala + H2O + O2 Sus scrofa
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Arg + H2O + O2 Sus scrofa
-
 5-guanidino-2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-Asn + H2O + O2 Sus scrofa
-
 2-oxosuccinamate + NH3 + H2O2
-
 ?
1.4.3.3 D-Asp + H2O + O2 Sus scrofa
-
 oxaloacetate + NH3 + H2O2
-
 ?
1.4.3.3 D-Gln + H2O + O2 Sus scrofa
-
 2-oxoglutaramate + NH3 + H2O2
-
 ?
1.4.3.3 D-Glu + H2O + O2 Sus scrofa
-
 alpha-ketoglutarate + NH3 + H2O2
-
 ?
1.4.3.3 D-His + H2O + O2 Sus scrofa
-
 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-Ile + H2O + O2 Sus scrofa
-
 3-methyl-2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-Leu + H2O + O2 Sus scrofa
-
 4-methyl-2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-Lys + H2O + O2 Sus scrofa
-
 6-amino-2-oxohexanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-Met + H2O + O2 Sus scrofa
-
 4-methylthio-2-oxobutanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-Phe + H2O + O2 Sus scrofa
-
 phenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Pro + H2O + O2 Sus scrofa
-
 2-oxopentanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-Ser + H2O + O2 Sus scrofa
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-Thr + H2O + O2 Sus scrofa
-
 2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
 ?
1.4.3.3 D-Trp + H2O + O2 Sus scrofa
-
 indol-3-pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Tyr + H2O + O2 Sus scrofa
-
 4-hydroxyphenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Val + H2O + O2 Sus scrofa
-
 2-oxoisovalerate + NH3 + H2O2
-
 ?
1.4.3.3 Gly + H2O + O2 Sus scrofa
-
 acetate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-Ala + H2O + O2
-
 Sus scrofa pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Arg + H2O + O2
-
 Sus scrofa 5-guanidino-2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-Asn + H2O + O2
-
 Sus scrofa 2-oxosuccinamate + NH3 + H2O2
-
 ?
1.4.3.3 D-Asp + H2O + O2
-
 Sus scrofa oxaloacetate + NH3 + H2O2
-
 ?
1.4.3.3 D-Gln + H2O + O2
-
 Sus scrofa 2-oxoglutaramate + NH3 + H2O2
-
 ?
1.4.3.3 D-Glu + H2O + O2
-
 Sus scrofa alpha-ketoglutarate + NH3 + H2O2
-
 ?
1.4.3.3 D-His + H2O + O2
-
 Sus scrofa 3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-Ile + H2O + O2
-
 Sus scrofa 3-methyl-2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-Leu + H2O + O2
-
 Sus scrofa 4-methyl-2-oxopentanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-Lys + H2O + O2
-
 Sus scrofa 6-amino-2-oxohexanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-Met + H2O + O2
-
 Sus scrofa 4-methylthio-2-oxobutanoate + NH3 + H2O2
-
 ?
1.4.3.3 D-Phe + H2O + O2
-
 Sus scrofa phenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Pro + H2O + O2
-
 Sus scrofa 2-oxopentanoic acid + NH3 + H2O2
-
 ?
1.4.3.3 D-Ser + H2O + O2
-
 Sus scrofa 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?
1.4.3.3 D-Thr + H2O + O2
-
 Sus scrofa 2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
 ?
1.4.3.3 D-Trp + H2O + O2
-
 Sus scrofa indol-3-pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Tyr + H2O + O2
-
 Sus scrofa 4-hydroxyphenylpyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-Val + H2O + O2
-
 Sus scrofa 2-oxoisovalerate + NH3 + H2O2
-
 ?
1.4.3.3 Gly + H2O + O2
-
 Sus scrofa acetate + NH3 + H2O2
-
 ?
1.4.3.3 L-Ala + H2O + O2 low activity Sus scrofa pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 L-Asp + H2O + O2 low activity Sus scrofa oxaloacetate + NH3 + H2O2
-
 ?
1.4.3.3 L-Pro + H2O + O2 low activity Sus scrofa 2-oxopentanoic acid + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAAO
-
 Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.3 0.09
-
 L-Ala at pH 7.0 and 37°C Sus scrofa
1.4.3.3 0.4
-
 L-Pro at pH 8.5 and 37°C Sus scrofa
1.4.3.3 0.7
-
 L-Pro at pH 7.5 and 37°C Sus scrofa
1.4.3.3 0.89
-
 L-Asp at pH 8.0 and 37°C Sus scrofa
1.4.3.3 0.95
-
 D-Asp at pH 8.0 and 37°C Sus scrofa
1.4.3.3 6.71
-
 L-Pro at pH 8.0 and 37°C Sus scrofa
1.4.3.3 9.4
-
 L-Ala at pH 9.8 and 37°C Sus scrofa
1.4.3.3 43.3
-
 D-Pro at pH 8.5 and 37°C Sus scrofa
1.4.3.3 50.2
-
 D-Pro at pH 7.5 and 37°C Sus scrofa
1.4.3.3 107.3
-
 D-Pro at pH 8.0 and 37°C Sus scrofa
1.4.3.3 133.3
-
 D-Ala at pH 9.8 and 37°C Sus scrofa
1.4.3.3 151.2
-
 D-Ala at pH 7.0 and 37°C Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD
-
 Sus scrofa