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Literature summary extracted from
- Role of alanine dehydrogenase of Mycobacterium tuberculosis during recovery from hypoxic nonreplicating persistence (2016), PLoS ONE, 11, e0155522 .
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.1.1 | Mycobacterium tuberculosis | P9WQB1 | - |
- |
| 1.4.1.1 | Mycobacterium tuberculosis H37Rv | P9WQB1 | - |
- |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.4.1.1 | Mycobacterium tuberculosis | both mRNA levels and enzymatic activity increase during entry into nonreplicating persistence. Expression is also induced in vitro by persistence-inducing stresses such as nitric oxide, and the gene is expressed at high levels in vivo during the initial lung infection in mice | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.4.1.1 | physiological function | both mRNA levels and enzymatic activities of isocitrate lyase, and alanine dehydrogenase increases during entry into nonreplicating persistence. Expression of alanine dehydrogenase is also induced in vitro by persistence-inducing stresses such as nitric oxide, and the gene is expressed at high levels in vivo during the initial lung infection in mice. Enzyme activity is maintained during extended hypoxia even after transcription levels decrease. A knockout mutant shows no reduction in anaerobic survival in vitro, but results in a significant lag in the resumption of growth after reoxygenation. During reactivation the mutant has an altered NADH/NAD ratio | Mycobacterium tuberculosis |
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