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Literature summary extracted from

  • Chiari, M.E.; Tosoni, L.; Joray, M.B.; Diaz Napal, G.N.; Palacios, S.M.; Ruiz, G.M.; Vera, D.M.; Carpinella, M.C.
    The inhibitory activity of plants from central Argentina on p-hydroxyphenylpyruvate dioxygenase. Isolation and mechanism of inhibition of a flavanone from Flourensia oolepis (2015), Planta Med., 81, 1382-1391 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 pinocembrin 5,7-dihydroxyflavanone, isolation from Flourensia oolepis ethanol extract, inhibition mechanism. Pinocembrin is a reversible inhibitor of the enzyme and acts as a noncompetitive inhibitor, molecular modeling studies and binding mode, overview. Comparison to other HPPD enzyme-inhibitor complexes Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.27 Fe2+ an iron-dependent, nonheme oxygenase enzyme Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2 Sus scrofa
-
 homogentisate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.27 commercial preparation
-
 Sus scrofa
-
1.13.11.27 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Sus scrofa homogentisate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.27 HPPD
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.27 0.0137
-
 pinocembrin pH and temperature not specified in the publication Sus scrofa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.27 0.0731
-
 pH and temperature not specified in the publication Sus scrofa pinocembrin

General Information

EC Number General Information Comment Organism
1.13.11.27 metabolism the enzyme is involved in the second step of the tyrosine degradation pathway, catalyzing the conversion of 4-hydroxyphenylpyruvate to homogentisate Sus scrofa