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Literature summary extracted from

  • Siregar, J.E.; Kurisu, G.; Kobayashi, T.; Matsuzaki, M.; Sakamoto, K.; Mi-ichi, F.; Watanabe, Y.; Hirai, M.; Matsuoka, H.; Syafruddin, D.; Marzuki, S.; Kita, K.
    Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex (2015), Parasitol. Int., 64, 295-300 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.8 5-n-heptyl-6-hydroxy-4,7-dioxobenzothiazole
-
 Plasmodium berghei
7.1.1.8 atovaquone
-
 Plasmodium berghei
7.1.1.8 Stigmatellin
-
 Plasmodium berghei

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.8 Plasmodium berghei
-
-
-
7.1.1.8 Plasmodium berghei ANKA
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.8 ubiquinol + ferricytochrome c
-
 Plasmodium berghei ubiquinone + ferrocytochrome c + H+
-
 ?
7.1.1.8 ubiquinol + ferricytochrome c
-
 Plasmodium berghei ANKA ubiquinone + ferrocytochrome c + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.8 cytochrome bc1 complex
-
 Plasmodium berghei
7.1.1.8 ubiquinol-cytochrome c reductase
-
 Plasmodium berghei

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.8 cytochrome c
-
 Plasmodium berghei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.8 0.000327
-
 at pH 8.0 and 25°C Plasmodium berghei atovaquone