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Literature summary extracted from

  • Spanaki, C.; Kotzamani, D.; Plaitakis, A.
    Widening spectrum of cellular and subcellular expression of human GLUD1 and GLUD2 glutamate dehydrogenases suggests novel functions (2017), Neurochem. Res., 42, 92-107 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.1.3 expression in Sf9 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.1.3 17beta-estradiol
-
 Homo sapiens
1.4.1.3 corticosterone
-
 Homo sapiens
1.4.1.3 dehydroepiandrosterone
-
 Homo sapiens
1.4.1.3 dehydrotestosterone
-
 Homo sapiens
1.4.1.3 diethylstilbestrol
-
 Homo sapiens
1.4.1.3 estriol
-
 Homo sapiens
1.4.1.3 pregnenolone
-
 Homo sapiens
1.4.1.3 progesterone
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.4.1.3 Homo sapiens P00367
-
-
1.4.1.3 Homo sapiens P49448
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.1.3 adrenal dense expression of both isoforms Gdh1 and Gdh2 Homo sapiens
-
1.4.1.3 brain expression of both isoforms Gdh1 and Gdh2 Homo sapiens
-
1.4.1.3 kidney expression of both isoforms Gdh1 and Gdh2 Homo sapiens
-
1.4.1.3 liver high expression of isoform Gdh1 Homo sapiens
-
1.4.1.3 additional information no expression in hepaocyte Homo sapiens
-
1.4.1.3 additional information no expression in Sertoli cells Homo sapiens
-
1.4.1.3 ovary both hGDH1 and hGDH2 are densely expressed in estrogen producing cells Homo sapiens
-
1.4.1.3 placenta both hGDH1 and hGDH2 are densely expressed in estrogen producing cells Homo sapiens
-
1.4.1.3 Sertoli cell strong expression 0f isoform Gdh2 Homo sapiens
-
1.4.1.3 testis expression of both isoforms Gdh1 and Gdh2 Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.1.3 0.001
-
 pH 8.0, temperature not specified in the publication Homo sapiens corticosterone
1.4.1.3 0.001
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens diethylstilbestrol
1.4.1.3 0.0015
-
 pH 8.0, temperature not specified in the publication Homo sapiens 17beta-estradiol
1.4.1.3 0.00167
-
 pH 8.0, temperature not specified in the publication Homo sapiens diethylstilbestrol
1.4.1.3 0.0021
-
 pH 8.0, temperature not specified in the publication Homo sapiens corticosterone
1.4.1.3 0.0025
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens corticosterone
1.4.1.3 0.0032
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens corticosterone
1.4.1.3 0.0071
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens diethylstilbestrol
1.4.1.3 0.0072
-
 pH 8.0, temperature not specified in the publication Homo sapiens dehydroepiandrosterone
1.4.1.3 0.008
-
 pH 8.0, temperature not specified in the publication Homo sapiens diethylstilbestrol
1.4.1.3 0.0113
-
 pH 8.0, temperature not specified in the publication Homo sapiens estriol
1.4.1.3 0.0117
-
 pH 8.0, temperature not specified in the publication Homo sapiens pregnenolone
1.4.1.3 0.0123
-
 pH 8.0, temperature not specified in the publication Homo sapiens progesterone
1.4.1.3 0.0151
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens 17beta-estradiol
1.4.1.3 0.0269
-
 pH 8.0, temperature not specified in the publication Homo sapiens 17beta-estradiol
1.4.1.3 0.0294
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens dehydroepiandrosterone
1.4.1.3 0.0494
-
 pH 8.0, temperature not specified in the publication Homo sapiens dehydrotestosterone
1.4.1.3 0.0541
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens pregnenolone
1.4.1.3 0.0589
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens progesterone
1.4.1.3 0.0692
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens 17beta-estradiol
1.4.1.3 0.0915
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens dehydrotestosterone
1.4.1.3 0.104
-
 pH 8.0, temperature not specified in the publication Homo sapiens pregnenolone
1.4.1.3 0.119
-
 pH 8.0, temperature not specified in the publication Homo sapiens progesterone
1.4.1.3 0.145
-
 pH 8.0, temperature not specified in the publication Homo sapiens estriol
1.4.1.3 0.189
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens estriol
1.4.1.3 0.216
-
 pH 8.0, temperature not specified in the publication Homo sapiens dehydroepiandrosterone
1.4.1.3 0.287
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens pregnenolone
1.4.1.3 0.316
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens estriol
1.4.1.3 0.396
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens dehydroepiandrosterone
1.4.1.3 0.494
-
 pH 8.0, temperature not specified in the publication Homo sapiens dehydrotestosterone
1.4.1.3 0.596
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens progesterone
1.4.1.3 0.814
-
 presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens dehydrotestosterone