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Literature summary extracted from

  • Yang, Y.; Yu, Y.; Li, X.; Li, J.; Wu, Y.; Yu, J.; Ge, J.; Huang, Z.; Jiang, L.; Rao, Y.; Yang, M.
    Target elucidation by cocrystal structures of NADH-ubiquinone oxidoreductase of Plasmodium falciparum (PfNDH2) with small molecule to eliminate drug-resistant malaria (2017), J. Med. Chem., 60, 1994-2005 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.1.1.2
-
 Plasmodium falciparum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
7.1.1.2 crystal structures of apoprotein an in complex with NADH and inhibitor 5-fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)-phenyl)quinolin-4(1H)-one Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 5-fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)-phenyl)quinolin-4(1H)-one inhibitor exhibits potency against both drug-resistant strains in vitro and parasite-infected mice in vivo via a potential allosteric mechanism. Inhibitor can be used in combination with dihydroartemisinin synergistically Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1.1.2 0.0349
-
 ubiquinone-1 pH 7.0, 25°C Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Plasmodium falciparum Q8I302
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + ubiquinone-1 + 5 H+[side 1]
-
 Plasmodium falciparum NAD+ + ubiquinol-1 + 4 H+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 PF3D7_0915000
-
 Plasmodium falciparum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
7.1.1.2 664
-
 ubiquinone-1 pH 7.0, 25°C Plasmodium falciparum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.2 0.0000037
-
 pH 7.0, 25°C Plasmodium falciparum 5-fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)-phenyl)quinolin-4(1H)-one