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Literature summary extracted from

  • Green, J.; Large, P.
    Subcellular localization and properties of partially purified dimethylamine and trimethylamine mono-oxygenase activities in Candida utilis (1984), J. Gen. Microbiol., 130, 2577-2588 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.238 2,2'-bipyridyl 12.7% inhibition at 0.5 mM Cyberlindnera jadinii
1.14.13.238 carbon monoxide complete inhibition at 30 s bubbling Cyberlindnera jadinii
1.14.13.238 Cuprizone 4.9% inhibition at 12.5 mM Cyberlindnera jadinii
1.14.13.238 EDTA 9.8% inhibition at 2.5 mM Cyberlindnera jadinii
1.14.13.238 hydroxylammonium chloride 99% inhibition at 0.5 mM Cyberlindnera jadinii
1.14.13.238 Lilly 53325 65.6% inhibition at 0.5 mM Cyberlindnera jadinii
1.14.13.238 mercaptoethanol 67.3% inhibition at 0.5 mM Cyberlindnera jadinii
1.14.13.238 additional information not inhibited by aminoacetonitrile, metyrapone, iodoacetamide, and N-ethylmaleimide Cyberlindnera jadinii
1.14.13.238 pargyline hydrochloride 15.7% inhibition at 1.16 mM Cyberlindnera jadinii
1.14.13.238 potassium cyanide 78.7% inhibition at 0.5 mM Cyberlindnera jadinii
1.14.13.238 Proadifen hydrochloride 71.7% inhibition at 0.5 mM Cyberlindnera jadinii
1.14.13.238 Sodium azide 14.6% inhibition at 5 mM Cyberlindnera jadinii
1.14.13.238 Sodium mersalyl 96.4% inhibition at 0.5 mM Cyberlindnera jadinii
1.14.13.238 sodium p-hydroxymercuribenzoate 94.1% inhibition at 0.2 mM Cyberlindnera jadinii
1.14.13.238 Tetramethylammonium chloride 20.7% inhibition at 5 mM Cyberlindnera jadinii
1.14.13.238 trans-2-phenylcyclopropylamine 60.6% inhibition at 0.25 mM Cyberlindnera jadinii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.238 0.000833
-
 diethylmethylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.00118
-
 trimethylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.004
-
 dimethylethylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.00444
-
 triethylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.0217
-
 Diethylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.0283
-
 dibutylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.0285
-
 NADH at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.0294
-
 methylbutylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.0368
-
 Dimethylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.0704
-
 methyloctylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.08
-
 Methylpropylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.093
-
 methylethylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.125
-
 ethylbutylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.166
-
 NADPH at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.278
-
 methylisopropylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.303
-
 dipropylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.654
-
 Methylethanolamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.8
-
 propylbutylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii
1.14.13.238 0.833
-
 ethylpropylamine with NADH as cosubstrate, at pH 7.0 and 25°C Cyberlindnera jadinii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.238 smooth endoplasmic reticulum
-
 Cyberlindnera jadinii 5790
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.238 Cyberlindnera jadinii
-
-
-
1.14.13.238 Cyberlindnera jadinii WY-3
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.238 Sepharose 2B column chromatography and 4-aminobutyl-Sepharose 4B column chromatography Cyberlindnera jadinii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.238 dibutylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii butylamine + acetaldehyde + NAD+ + H2O
-
 ?
1.14.13.238 dibutylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii WY-3 butylamine + acetaldehyde + NAD+ + H2O
-
 ?
1.14.13.238 diethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ethylamine + acetaldehyde + NAD+ + H2O
-
 ?
1.14.13.238 diethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii WY-3 ethylamine + acetaldehyde + NAD+ + H2O
-
 ?
1.14.13.238 diethylmethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 diethylmethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii WY-3 ?
-
 ?
1.14.13.238 dimethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii methylamine + formaldehyde + NAD+ + H2O
-
 ?
1.14.13.238 dimethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii WY-3 methylamine + formaldehyde + NAD+ + H2O
-
 ?
1.14.13.238 dimethylamine + NADPH + H+ + O2
-
 Cyberlindnera jadinii methylamine + formaldehyde + NADP+ + H2O
-
 ?
1.14.13.238 dimethylamine + NADPH + H+ + O2
-
 Cyberlindnera jadinii WY-3 methylamine + formaldehyde + NADP+ + H2O
-
 ?
1.14.13.238 dimethylethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 dipropylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii propylamine + acetaldehyde + NAD+ + H2O
-
 ?
1.14.13.238 ethylbutylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 ethylpropylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 methylbutylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 methylethanolamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 methylethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 methylisopropylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 methyloctylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 methylpropylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 propylbutylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 triethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?
1.14.13.238 trimethylamine + NADH + H+ + O2
-
 Cyberlindnera jadinii ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.238 dimethylamine mono-oxygenase
-
 Cyberlindnera jadinii

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.14.13.238 23
-
 the enzyme remains stable after 6 h at 23°C Cyberlindnera jadinii

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.238 FAD
-
 Cyberlindnera jadinii
1.14.13.238 FMN
-
 Cyberlindnera jadinii
1.14.13.238 NADH NADH is the more efficient donor compared to NADPH Cyberlindnera jadinii
1.14.13.238 NADPH NADH is the more efficient donor compared to NADPH Cyberlindnera jadinii