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Literature summary extracted from

  • Burns, K.; Baumgart, S.; Dorrestein, P.; Zhai, H.; McLafferty, F.; Begley, T.
    Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis (2005), J. Am. Chem. Soc., 127, 11602-11603 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.1.6 EDTA complete loss of activity, presence of Zn2+ restores the activity Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.13.1.6 Zn2+ presence of Zn2+ restores the activity lost by incubation with EDTA Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.13.1.6 Mycobacterium tuberculosis P9WHS1
-
-
3.13.1.6 Mycobacterium tuberculosis H37Rv P9WHS1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.1.6 [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O
-
 Mycobacterium tuberculosis [CysO sulfur-carrier protein]-Gly-NH-CH2-COOH + L-cysteine
-
 ?
3.13.1.6 [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O
-
 Mycobacterium tuberculosis H37Rv [CysO sulfur-carrier protein]-Gly-NH-CH2-COOH + L-cysteine
-
 ?
3.13.1.6 [CysO sulfur-carrier protein]-His10-L-Ala-NH-CH2-C(O)-S-L-cysteine + H2O
-
 Mycobacterium tuberculosis [CysO sulfur-carrier protein]-His-10-L-Ala-NH-CH2-COOH + L-cysteine
-
 ?
3.13.1.6 [CysO sulfur-carrier protein]-His10-L-Ala-NH-CH2-C(O)-S-L-cysteine + H2O
-
 Mycobacterium tuberculosis H37Rv [CysO sulfur-carrier protein]-His-10-L-Ala-NH-CH2-COOH + L-cysteine
-
 ?
3.13.1.6 [CysO sulfur-carrier protein]-His10-L-Cys-NH-CH2-C(O)-S-L-cysteine + H2O
-
 Mycobacterium tuberculosis [CysO sulfur-carrier protein]-His-10-L-Cys-NH-CH2-COOH + L-cysteine
-
 ?
3.13.1.6 [CysO sulfur-carrier protein]-His10-L-Cys-NH-CH2-C(O)-S-L-cysteine + H2O
-
 Mycobacterium tuberculosis H37Rv [CysO sulfur-carrier protein]-His-10-L-Cys-NH-CH2-COOH + L-cysteine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.13.1.6 More sequence contains the JAMM motif Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
3.13.1.6 CysO-cysteine peptidase
-
 Mycobacterium tuberculosis
3.13.1.6 mec
-
 Mycobacterium tuberculosis
3.13.1.6 Rv1334
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
3.13.1.6 physiological function in cysteine biosynthesis, cysteine synthase M catalyzes the addition of cysteine to the carboxy terminus of the protein-bound thiocarboxylate to generate a CysO-cysteine adduct. Protease Mec hydrolyzes the CysO-cysteine adduct to release cysteine and regenerate CysO Mycobacterium tuberculosis