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Literature summary extracted from

  • Wetzl, D.; Bolsinger, J.; Nestl, B.; Hauer, B.
    alpha-Hydroxylation of carboxylic acids catalyzed by taurine dioxygenase (2016), ChemCatChem, 8, 1361-1366 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.17 expression in Escherichia coli BL21(DE3) Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.17 F206Y the conversions of the improved catalyst increases by at least 140% compared to that of the wild-type enzyme and shows broadened substrate scope Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.17 Escherichia coli P37610
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.17
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.17 4-aminobutyric acid + 2-oxoglutarate + O2 activity with mutant enzyme F206Y is 4.7fold higher than activity with wild-type enzyme Escherichia coli D-2-hydroxy-4-aminobutyric acid + succinate + CO2
-
?
1.14.11.17 5-aminovaleric acid + 2-oxoglutarate + O2 activity with mutant enzyme F206Y is 4.4fold higher than activity with wild-type enzyme Escherichia coli D-2-hydroxy-5-aminovaleric acid + succinate + CO2
-
?
1.14.11.17 6-aminocaproic acid + 2-oxoglutarate + O2 mutant enzyme F206Y shows low activity. No activity with the wild-type enzyme Escherichia coli D-2-hydroxy-6-aminocaproic acid + succinate + CO2
-
?
1.14.11.17 alpha-methyl-beta-alanine + 2-oxoglutarate + O2 mutant enzyme F206Y shows low activity. No activity with the wild-type enzyme Escherichia coli 3-amino-2-hydroxy-2-methylpropanoic acid + succinate + CO2
-
?
1.14.11.17 beta-alanine + 2-oxoglutarate + O2 activity with mutant enzyme F206Y is 2.4fold higher than activity with wild-type enzyme Escherichia coli D-isoserine + succinate + CO2
-
?
1.14.11.17 butyric acid + 2-oxoglutarate + O2 mutant enzyme F206Y shows low activity. No activity with the wild-type enzyme Escherichia coli 2-hydroxybutyric acid + succinate + CO2
-
?
1.14.11.17 propionic acid + 2-oxoglutarate + O2 mutant enzyme F206Y shows low activity. No activity with the wild-type enzyme Escherichia coli 2-hydroxypropionic acid + succinate + CO2
-
?
1.14.11.17 valeric acid + 2-oxoglutarate + O2 mutant enzyme F206Y shows low activity. No activity with the wild-type enzyme Escherichia coli 2-hydroxyvaleric acid + succinate + CO2
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.17 TauD
-
Escherichia coli