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Literature summary extracted from

  • Dierks, T.; Dickmanns, A.; Preusser-Kunze, A.; Schmidt, B.; Mariappan, M.; von Figura, K.; Ficner, R.; Rudolph, M.G.
    Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme (2005), Cell, 121, 541-552 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.8.3.7 A177P the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 A279V the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 A348P the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 C218Y the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 C336R the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 C346W the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 G247R the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 G263V the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 N259I the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 P266L the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 R224W the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 R345C the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 R349Q the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 R349W the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 R364C the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 S155P the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 S234R the mutant show reduced enzyme activity Homo sapiens
1.8.3.7 W179S the mutant show reduced enzyme activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.3.7 Ca2+ contains 2 Ca2+ ions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.3.7 a [sulfatase]-L-cysteine + O(2) + a thiol Homo sapiens
-
 a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.3.7 Homo sapiens Q8NBK3
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.8.3.7 glycoprotein N-glycosylation at Asn141 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.3.7 a [sulfatase]-L-cysteine + O(2) + a thiol
-
 Homo sapiens a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.3.7 FGE
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.8.3.7 malfunction enzyme inactivity results in multiple sulfatase deficiency, a fatal autosomal recessive syndrome Homo sapiens