BRENDA - Enzyme Database show

Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors

Thangavelu, B.; Bhansali, P.; Viola, R.E.; Bioorg. Med. Chem. 23, 6622-6631 (2015)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
1.2.1.11
drug development
ASADH family enzymes are attractive potential targets for development of antibiotics with novel modes of action
Streptococcus pneumoniae
1.2.1.11
drug development
ASADH family enzymes are attractive potential targets for development of antibiotics with novel modes of action
Vibrio cholerae
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.11
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
Streptococcus pneumoniae
1.2.1.11
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
Vibrio cholerae
1.2.1.11
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
Streptococcus pneumoniae
1.2.1.11
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
Vibrio cholerae
1.2.1.11
additional information
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening. ASADH inhibitor development, overview
Streptococcus pneumoniae
1.2.1.11
additional information
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening. ASADH inhibitor development, overview. No inhibition by 4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid, N-(4-bromobenzyl)-N-carboxyethyl-3,4-dicarboxybenzylamine , and N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
Vibrio cholerae
1.2.1.11
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-carboxyethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-carboxyethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
Streptococcus pneumoniae
-
L-4-aspartyl phosphate + NADPH + H+
-
-
r
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
Vibrio cholerae
-
L-4-aspartyl phosphate + NADPH + H+
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.2.1.11
Streptococcus pneumoniae
-
-
-
1.2.1.11
Vibrio cholerae
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
742070
Streptococcus pneumoniae
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
742070
Vibrio cholerae
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.2.1.11
22
-
assay at room temperature
Streptococcus pneumoniae
1.2.1.11
22
-
assay at room temperature
Vibrio cholerae
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.2.1.11
8.6
-
assay at
Streptococcus pneumoniae
1.2.1.11
8.6
-
assay at
Vibrio cholerae
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.11
NADP+
-
Streptococcus pneumoniae
1.2.1.11
NADP+
-
Vibrio cholerae
1.2.1.11
NADPH
-
Streptococcus pneumoniae
1.2.1.11
NADPH
-
Vibrio cholerae
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.2.1.11
0.009
-
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.012
-
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.016
-
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.024
-
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.036
-
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.054
-
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.057
-
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.063
-
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.072
-
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.176
-
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.22
-
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.229
-
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.246
-
N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.276
-
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.296
-
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.296
-
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.297
-
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.303
-
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.324
-
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.329
-
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.396
-
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.427
-
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.43
-
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.441
-
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.442
-
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.476
-
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.498
-
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.509
-
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.524
-
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.528
-
N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.529
-
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.54
-
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.608
-
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.609
-
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.628
-
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.629
-
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.634
-
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.635
-
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.639
-
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.648
-
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.649
-
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.654
-
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.655
-
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.663
-
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.663
-
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.665
-
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.675
-
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.678
-
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.684
-
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.69
-
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.692
-
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.696
-
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.698
-
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.708
-
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.721
-
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.724
-
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.727
-
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.737
-
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.749
-
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
1.1
-
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
2.4
-
N-carboxyethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
3.6
-
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
3.8
-
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
Application (protein specific)
EC Number
Application
Commentary
Organism
1.2.1.11
drug development
ASADH family enzymes are attractive potential targets for development of antibiotics with novel modes of action
Streptococcus pneumoniae
1.2.1.11
drug development
ASADH family enzymes are attractive potential targets for development of antibiotics with novel modes of action
Vibrio cholerae
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.11
NADP+
-
Streptococcus pneumoniae
1.2.1.11
NADP+
-
Vibrio cholerae
1.2.1.11
NADPH
-
Streptococcus pneumoniae
1.2.1.11
NADPH
-
Vibrio cholerae
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.11
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
Streptococcus pneumoniae
1.2.1.11
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
Vibrio cholerae
1.2.1.11
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
Streptococcus pneumoniae
1.2.1.11
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
-
Vibrio cholerae
1.2.1.11
additional information
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening. ASADH inhibitor development, overview
Streptococcus pneumoniae
1.2.1.11
additional information
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening. ASADH inhibitor development, overview. No inhibition by 4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid, N-(4-bromobenzyl)-N-carboxyethyl-3,4-dicarboxybenzylamine , and N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
Vibrio cholerae
1.2.1.11
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-carboxyethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-carboxyethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
1.2.1.11
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Streptococcus pneumoniae
1.2.1.11
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
-
Vibrio cholerae
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.2.1.11
0.009
-
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.012
-
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.016
-
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.024
-
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.036
-
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.054
-
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.057
-
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.063
-
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.072
-
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.176
-
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.22
-
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.229
-
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.246
-
N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.276
-
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.296
-
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.296
-
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.297
-
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.303
-
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.324
-
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.329
-
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.396
-
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.427
-
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.43
-
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.441
-
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.442
-
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.476
-
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.498
-
N-acetonitrile, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.509
-
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.524
-
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.528
-
N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.529
-
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.54
-
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
0.608
-
N-(4-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.609
-
4-([[(1S)-1-carboxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.628
-
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.629
-
N-(4-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.634
-
N-(4-biphenyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.635
-
N-(4-carboxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.639
-
N-(4-(2-perfluoropropyl))-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.648
-
N-(4-t-butylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.649
-
N-(4-carboxamidebenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.654
-
4-([[(1S)-1-carboxy-2-hydroxyethyl]amino]methyl)benzene-1,2-dicarboxylic acid
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.655
-
N-acetal-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.663
-
N-(4-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.663
-
N-allyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.665
-
N-(3-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.675
-
N-methyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.678
-
N-(3-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.684
-
N-(3-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.69
-
N-(3-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.692
-
N-(ethylmorpholino)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.696
-
N-benzyl, N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.698
-
N-(4-difluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.708
-
N-(2-trifluoromethoxybenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.721
-
N-(2-methylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.724
-
N-(2-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.727
-
N-(2-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.737
-
N-(2-bromobenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
0.749
-
N-(1-naphthyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
1.1
-
N-((4-(2-benzyl)vinyl)benzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Vibrio cholerae
1.2.1.11
2.4
-
N-carboxyethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
3.6
-
N-(4-bromobenzyl)-N-(2-carboxy)ethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
1.2.1.11
3.8
-
N-(4-trifluoromethylbenzyl)-N-carboxymethyl-3,4-dicarboxybenzylamine
pH 8.6, 22°C
Streptococcus pneumoniae
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
Streptococcus pneumoniae
-
L-4-aspartyl phosphate + NADPH + H+
-
-
r
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
Vibrio cholerae
-
L-4-aspartyl phosphate + NADPH + H+
-
-
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
742070
Streptococcus pneumoniae
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
742070
Vibrio cholerae
L-4-aspartyl phosphate + NADPH + H+
-
-
-
r
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.2.1.11
22
-
assay at room temperature
Streptococcus pneumoniae
1.2.1.11
22
-
assay at room temperature
Vibrio cholerae
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.2.1.11
8.6
-
assay at
Streptococcus pneumoniae
1.2.1.11
8.6
-
assay at
Vibrio cholerae
General Information
EC Number
General Information
Commentary
Organism
1.2.1.11
evolution
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening
Streptococcus pneumoniae
1.2.1.11
evolution
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening
Vibrio cholerae
1.2.1.11
metabolism
aspartate-beta-semialdehyde dehydrogenase lies at the first branch point in the aspartate metabolic pathway which leads to the biosynthesis of several essential amino acids and some important metabolites. This pathway is crucial for many metabolic processes in plants and microbes like bacteria and fungi, but is absent in mammals
Streptococcus pneumoniae
1.2.1.11
metabolism
aspartate-beta-semialdehyde dehydrogenase lies at the first branch point in the aspartate metabolic pathway which leads to the biosynthesis of several essential amino acids and some important metabolites. This pathway is crucial for many metabolic processes in plants and microbes like bacteria and fungi, but is absent in mammals
Vibrio cholerae
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.2.1.11
evolution
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening
Streptococcus pneumoniae
1.2.1.11
evolution
the ASADH enzyme family shares the same substrate binding and active site catalytic groups, but the enzymes from representative bacterial and fungal species show different inhibition patterns when previously screened against low molecular weight inhibitors identified from fragment library screening
Vibrio cholerae
1.2.1.11
metabolism
aspartate-beta-semialdehyde dehydrogenase lies at the first branch point in the aspartate metabolic pathway which leads to the biosynthesis of several essential amino acids and some important metabolites. This pathway is crucial for many metabolic processes in plants and microbes like bacteria and fungi, but is absent in mammals
Streptococcus pneumoniae
1.2.1.11
metabolism
aspartate-beta-semialdehyde dehydrogenase lies at the first branch point in the aspartate metabolic pathway which leads to the biosynthesis of several essential amino acids and some important metabolites. This pathway is crucial for many metabolic processes in plants and microbes like bacteria and fungi, but is absent in mammals
Vibrio cholerae