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Literature summary extracted from

  • Celis, A.I.; Geeraerts, Z.; Ngmenterebo, D.; Machovina, M.M.; Kurker, R.C.; Rajakumar, K.; Ivancich, A.; Rodgers, K.R.; Lukat-Rodgers, G.S.; DuBois, J.L.
    A dimeric chlorite dismutase exhibits O2-generating activity and acts as a chlorite antioxidant in Klebsiella pneumoniae MGH 78578 (2015), Biochemistry, 54, 434-446 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.49 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) presence of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) modestly increases turnover number Klebsiella pneumoniae
1.13.11.49 2-chloro-5,5-dimethyl-1,3-cyclohexanedione presence of 2-chloro-5,5-dimethyl-1,3-cyclohexanedione modestly increases turnover number Klebsiella pneumoniae
1.13.11.49 guaiacol presence of guaicol modestly increases turnover number Klebsiella pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.49 Chlorite chlorite acts a suicide substrate. Loss of activity is correlated with destruction of the heme and also some degree of protein damage Klebsiella pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.49 Klebsiella pneumoniae
-
-
-
1.13.11.49 Klebsiella pneumoniae MGH 78578
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.49 chlorite
-
Klebsiella pneumoniae chloride + O2
-
?
1.13.11.49 chlorite
-
Klebsiella pneumoniae MGH 78578 chloride + O2
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.13.11.49 1900
-
Chlorite pH 5.0, 20°C Klebsiella pneumoniae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.49 5
-
-
Klebsiella pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.49 heme at pH 6.0, ferric Cld exhibits a Soret band maximum at 405 nm, a broad alpha/beta band envelope at 505 nm with a small shoulder at 540 nm, and a charge transfer band at 645 nm Klebsiella pneumoniae

General Information

EC Number General Information Comment Organism
1.13.11.49 physiological function wild-type strains have a significant growth advantage in the presence of chlorate relative to a Cld knockout strain, specifically under nitrate-respiring conditions Klebsiella pneumoniae

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.13.11.49 2500
-
Chlorite pH 5.0, 20°C Klebsiella pneumoniae