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Literature summary extracted from

  • Oogai, Y.; Yamaguchi, M.; Kawada-Matsuo, M.; Sumitomo, T.; Kawabata, S.; Komatsuzawa, H.
    Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum (2016), Appl. Environ. Microbiol., 82, 6150-6157 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.11 additional information construction of and screening of a library of 2914 transposon-insertional mutants in the Staphylococcus aureus MW2 strain, identification of aspartate semialdehyde dehydrogenase (asd)-inactivated mutant, and inactivated mutants of lysA and thrC defective in lysine and threonine bioynthesis. Identification of Tn551 insertion sites, the Tn551 insertion sites of M3-91 and M17-9 are 276 bp and 347 bp from the initiation of the asd gene, respectively Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+ Staphylococcus aureus
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+ Staphylococcus aureus MW2
-
 L-4-aspartyl phosphate + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Staphylococcus aureus
-
 methicillin resistant
-
1.2.1.11 Staphylococcus aureus MW2
-
 methicillin resistant
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Staphylococcus aureus L-4-aspartyl phosphate + NADPH + H+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Staphylococcus aureus MW2 L-4-aspartyl phosphate + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.2.1.11 Asd
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.11 NADP+
-
 Staphylococcus aureus
1.2.1.11 NADPH
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
1.2.1.11 malfunction the aspartate semialdehyde dehydrogenase (asd)-inactivated mutant exhibits significantly reduced growth in calf serum compared with the wild-type. The mutant also exhibits significantly reduced growth in medium, mimicking the concentrations of amino acids and glucose in calf serum, but can be recovered by addition of lysine and threonine Staphylococcus aureus
1.2.1.11 metabolism Asd is an essential enzyme for the biosynthesis of lysine, methionine, and threonine from aspartate Staphylococcus aureus