EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.8.4.11 | additional information | site-directed mutagenesis confirms that Cys56 is the peroxidatic cysteine that is oxidized to sulfenic acid, while Cys204 and Cys213 are the resolving Cys residues that form an intramolecular disulfide bond | Corynebacterium glutamicum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.4.11 | Corynebacterium glutamicum | Q8NLL5 | - |
- |
1.8.4.11 | Corynebacterium glutamicum DSM 20300 | Q8NLL5 | - |
- |
1.20.4.3 | Corynebacterium glutamicum | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.11 | additional information | MsrA can reduce methionine sulfoxide via both the thioredoxin/thioredoxin reductase (Trx/TrxR) and mycoredoxin 1/mycothione reductase/mycothiol (Mrx1/Mtr/MSH) pathways. Mrx1 reduces the sulfenic acid intermediate via the formation of an S-mycothiolated MsrA intermediate which is then recycled by mycoredoxin and a second molecule of mycothiol, similarly to the glutathione/glutaredoxin/glutathione reductase system. Trx reduces the Cys204-Cys213 disulfide bond in MsrA produced during methionine sulfoxide reduction via the formation of a transient intermolecular disulfide bond between Trx and MsrA | Corynebacterium glutamicum | ? | - |
? | |
1.8.4.11 | additional information | MsrA can reduce methionine sulfoxide via both the thioredoxin/thioredoxin reductase (Trx/TrxR) and mycoredoxin 1/mycothione reductase/mycothiol (Mrx1/Mtr/MSH) pathways. Mrx1 reduces the sulfenic acid intermediate via the formation of an S-mycothiolated MsrA intermediate which is then recycled by mycoredoxin and a second molecule of mycothiol, similarly to the glutathione/glutaredoxin/glutathione reductase system. Trx reduces the Cys204-Cys213 disulfide bond in MsrA produced during methionine sulfoxide reduction via the formation of a transient intermolecular disulfide bond between Trx and MsrA | Corynebacterium glutamicum DSM 20300 | ? | - |
? | |
1.8.4.11 | peptide-L-methionine (S)-S-oxide + mycothiol | - |
Corynebacterium glutamicum | peptide-L-methionine + mycothione + H2O | - |
? | |
1.8.4.11 | peptide-L-methionine (S)-S-oxide + mycothiol | - |
Corynebacterium glutamicum DSM 20300 | peptide-L-methionine + mycothione + H2O | - |
? | |
1.8.4.11 | peptide-L-methionine (S)-S-oxide + thioredoxin | - |
Corynebacterium glutamicum | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
1.8.4.11 | peptide-L-methionine (S)-S-oxide + thioredoxin | - |
Corynebacterium glutamicum DSM 20300 | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
1.20.4.3 | additional information | the enzyme reduces the sulfenic acid intermediate via the formation of an S-mycothiolated methionine sulfoxide reductase A intermediate which is then recycled by mycoredoxin and the second molecule of mycothiol | Corynebacterium glutamicum | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.20.4.3 | Mrx1 | - |
Corynebacterium glutamicum |
1.20.4.3 | mycoredoxin 1 | - |
Corynebacterium glutamicum |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.8.4.11 | Corynebacterium glutamicum | induced expression under various stresses, regulated directly by the stress-responsive extracytoplasmic-function sigma factor SigH | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.8.4.11 | physiological function | Deletion of the msrA gene results in decrease of cell viability, increase of ROS production, and increase of protein carbonylation levels under various stress conditions. MsrA can reduce methionine sulfoxide via both the thioredoxin/thioredoxin reductase (Trx/TrxR) and mycoredoxin 1/mycothione reductase/mycothiol (Mrx1/Mtr/MSH) pathways | Corynebacterium glutamicum |