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Literature summary extracted from

  • Froemmel, J.; Sebela, M.; Demo, G.; Lenobel, R.; Pospisil, T.; Soural, M.; Kopecny, D.
    N-acyl-omega-aminoaldehydes are efficient substrates of plant aminoaldehyde dehydrogenases (2015), Amino Acids, 47, 175-187 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.19 2,2-dimethyl-4-propionylaminobutanal causes substrate inhibition at high concentration Pisum sativum
1.2.1.19 3-methyl-3-butyrylaminopropanal causes substrate inhibition at high concentration Pisum sativum
1.2.1.19 3-methyl-4-butyrylaminobutanal causes substrate inhibition at high concentration Pisum sativum
1.2.1.19 3-propionylaminopropanal causes substrate inhibition at high concentration Pisum sativum
1.2.1.19 4-acetamidobutanal causes substrate inhibition at high concentration Pisum sativum
1.2.1.19 4-propionylaminobutanal causes substrate inhibition at high concentration Pisum sativum
1.2.1.19 additional information isozyme PsAMADH 1 shows no substrate inhibition Pisum sativum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.19 0.00727
-
 3-aminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.0392
-
 3-adipylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.0459
-
 4-aminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.0651
-
 3-propionylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.0718
-
 3-aminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.0927
-
 4-propionylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.0935
-
 2-methyl-3-propionylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.109
-
 3-acetaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.12
-
 3-valerylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.13
-
 3-methyl-3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.137
-
 3-methyl-3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.153
-
 4-aminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.183
-
 2-methyl-3-propionylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.189
-
 2-methyl-4-propionylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.226
-
 3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.227
-
 3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.242
-
 4-acetaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.264
-
 4-butyrylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.266
-
 2,2-dimethyl-3-propionylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.268
-
 3-acetaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.271
-
 3-valerylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.304
-
 4-valerylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.327
-
 4-propionylaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.361
-
 3-methyl-3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.366
-
 2-methyl-3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.397
-
 2-methyl-3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.431
-
 3-adipylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.469
-
 2-methyl-3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.477
-
 2,2-dimethyl-3-propionylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.49 2 3-propionylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.506
-
 2,2-dimethyl-4-propionylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.516
-
 4-acetaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.525
-
 2-methyl-4-propionylaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.531
-
 3-methyl-3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.629
-
 4-valerylaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.638
-
 2-methyl-3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 0.738
-
 4-butyrylaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.42
-
 2,2-dimethyl-4-aminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.19 3-aminopropanal + NAD+ + H2O Pisum sativum
-
 3-aminopropanoate + NADH + H+
-
 ?
1.2.1.19 4-aminobutanal + NAD+ + H2O Pisum sativum
-
 4-aminobutanoate + NADH + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.19 Pisum sativum Q8VWZ1
-
-
1.2.1.19 Pisum sativum Q93YB2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.19 2,2-dimethyl-3-propionylaminopropanal + NAD+ + H2O
-
 Pisum sativum 2,2-dimethyl-3-propionylaminopropanoate + NADH + 2 H+
-
 ?
1.2.1.19 2,2-dimethyl-4-aminobutanal + NAD+ + H2O
-
 Pisum sativum 2,2-dimethyl-4-aminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 2,2-dimethyl-4-propionylaminobutanal + NAD+ + H2O
-
 Pisum sativum 2,2-dimethyl-4-propionylaminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 2-methyl-3-butyrylaminopropanal + NAD+ + H2O
-
 Pisum sativum 2-methyl-3-butyrylaminopropanoate + NADH + 2 H+
-
 ?
1.2.1.19 2-methyl-3-propionylaminopropanal + NAD+ + H2O
-
 Pisum sativum 2-methyl-3-propionylaminopropanoate + NADH + 2 H+
-
 ?
1.2.1.19 2-methyl-4-aminobutanal + NAD+ + H2O
-
 Pisum sativum 2-methyl-4-aminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 2-methyl-4-propionylaminobutanal + NAD+ + H2O
-
 Pisum sativum 2-methyl-4-propionylaminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 3-acetaminopropanal + NAD+ + H2O
-
 Pisum sativum 3-acetaminopropanoate + NADH + 2 H+
-
 ?
1.2.1.19 3-adipylaminopropanal + NAD+ + H2O
-
 Pisum sativum 3-adipylaminopropanoate + NADH + 2 H+
-
 ?
1.2.1.19 3-aminopropanal + NAD+ + H2O
-
 Pisum sativum 3-aminopropanoate + NADH + H+
-
 ?
1.2.1.19 3-butyrylaminopropanal + NAD+ + H2O
-
 Pisum sativum 3-butyrylaminpropanoate + NADH + 2 H+
-
 ?
1.2.1.19 3-methyl-3-butyrylaminopropanal + NAD+ + H2O
-
 Pisum sativum 3-methyl-3-butyrylaminopropanoate + NADH + 2 H+
-
 ?
1.2.1.19 3-methyl-4-aminobutanal + NAD+ + H2O
-
 Pisum sativum 3-methyl-4-aminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 3-propionylaminopropanal + NAD+ + H2O
-
 Pisum sativum 3-propionylaminopropanoate + NADH + 2 H+
-
 ?
1.2.1.19 3-valerylaminopropanal + NAD+ + H2O
-
 Pisum sativum 3-valerylaminopropanoate + NADH + 2 H+
-
 ?
1.2.1.19 4-acetaminobutanal + NAD+ + H2O
-
 Pisum sativum 4-acetaminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 4-aminobutanal + NAD+ + H2O
-
 Pisum sativum 4-aminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 4-butyrylaminobutanal + NAD+ + H2O
-
 Pisum sativum 4-butyrylaminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 4-propionylaminobutanal + NAD+ + H2O
-
 Pisum sativum 4-propionylaminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 4-valerylaminobutanal + NAD+ + H2O
-
 Pisum sativum 4-valerylaminobutanoate + NADH + 2 H+
-
 ?
1.2.1.19 additional information design and synthesis of N-acyl derivates of 3-aminopropanal and 4-aminobutanal and confirmed as substrates of AMADH isoenzyme PsAMADH 1, molecular docking indicates the possible auxiliary role of Tyr163, Ser295 and Gln451 in binding of the substrates. Substrate specificity and molecular docking, overview. The substrate properties of N-acyl-omega-aminoaldehydes arise from their proper binding at the active site, which is facilitated by interactions with amino acid residues in the substrate channel such as Tyr163 Pisum sativum ?
-
 ?
1.2.1.19 additional information design and synthesis of N-acyl derivates of 3-aminopropanal and 4-aminobutanal and confirmed as substrates of AMADH isoenzyme PsAMADH 2, molecular docking indicates the possible auxiliary role of Tyr163, Ser295 and Gln451 in binding of the substrates. Substrate specificity and molecular docking, overview. The substrate properties of N-acyl-omega-aminoaldehydes arise from their proper binding at the active site, which is facilitated by interactions with amino acid residues in the substrate channel such as Tyr163 Pisum sativum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.19 4-aminobutyraldehyde dehydrogenase
-
 Pisum sativum
1.2.1.19 ABALDH
-
 Pisum sativum
1.2.1.19 AMADH
-
 Pisum sativum
1.2.1.19 aminoaldehyde dehydrogenase
-
 Pisum sativum
1.2.1.19 PsAMADH 1
-
 Pisum sativum
1.2.1.19 PsAMADH 2
-
 Pisum sativum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.19 30
-
 assay at Pisum sativum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.1.19 1.03
-
 3-adipylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.05
-
 4-valerylaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.2
-
 2-methyl-3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.22
-
 3-methyl-3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.24
-
 3-methyl-3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.39
-
 4-butyrylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.41
-
 2,2-dimethyl-3-propionylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.56
-
 2-methyl-3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.6
-
 4-butyrylaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.63
-
 4-propionylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.65
-
 4-propionylaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 1.93
-
 4-valerylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 2.02
-
 3-valerylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 2.03
-
 2-methyl-3-propionylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 2.32
-
 2-methyl-4-propionylaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 2.41
-
 3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 2.49
-
 4-acetaminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 2.84
-
 4-acetaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 2.87
-
 2-methyl-3-butyrylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 3.02
-
 4-aminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 3.1
-
 4-aminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 3.2
-
 2,2-dimethyl-4-aminobutanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 3.4
-
 3-propionylaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 3.61
-
 3-acetaminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 3.65
-
 3-aminopropanal isozyme PsAMADH 1, pH 9.0, 30°C Pisum sativum
1.2.1.19 4.08
-
 2-methyl-4-propionylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 5.8
-
 2,2-dimethyl-4-propionylaminobutanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 6.49
-
 2-methyl-3-propionylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 6.84
-
 3-methyl-3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 7.72
-
 3-propionylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 8.13
-
 3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 8.78
-
 3-adipylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 9.42
-
 3-aminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 9.54
-
 3-methyl-3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 11
-
 3-valerylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 12.1
-
 2-methyl-3-butyrylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 13.9
-
 3-acetaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum
1.2.1.19 14.4
-
 2,2-dimethyl-3-propionylaminopropanal isozyme PsAMADH 2, pH 9.0, 30°C Pisum sativum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.19 9
-
 assay at Pisum sativum

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.19 NAD+
-
 Pisum sativum

General Information

EC Number General Information Comment Organism
1.2.1.19 evolution the enzyme is a member of the aldehyde dehydrogenase 10 family Pisum sativum