Literature summary extracted from

Guan, X.L.; Wu, P.F.; Wang, S.; Zhang, J.J.; Shen, Z.C.; Luo, H.; Chen, H.; Long, L.H.; Chen, J.G.; Wang, F.
Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism (2017), Aging Cell, 16, 226-236 .

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.4.11	Caenorhabditis elegans	O02089	-	-
1.8.4.11	Drosophila melanogaster	-	-	-
1.8.4.11	Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.4.11	dimethylsulfide + thioredoxin disulfide + H2O	-	Drosophila melanogaster	dimethylsulfoxide + thioredoxin	-	?
1.8.4.11	dimethylsulfide + thioredoxin disulfide + H2O	-	Rattus norvegicus	dimethylsulfoxide + thioredoxin	-	?
1.8.4.11	dimethylsulfide + thioredoxin disulfide + H2O	-	Caenorhabditis elegans	dimethylsulfoxide + thioredoxin	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.8.4.11	MsrA	-	Drosophila melanogaster
1.8.4.11	MsrA	-	Rattus norvegicus
1.8.4.11	MsrA	-	Caenorhabditis elegans

General Information

EC Number	General Information	Comment	Organism
1.8.4.11	physiological function	supplement of dimethylsulfide leads to cytoprotection and extends longevity. MsrA knockdown abolishes the cytoprotective effect and the longevity benefits of dimethylsulfide	Drosophila melanogaster
1.8.4.11	physiological function	supplement of dimethylsulfide leads to cytoprotection and extends longevity. MsrA knockdown abolishes the cytoprotective effect and the longevity benefits of dimethylsulfide	Caenorhabditis elegans

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Release 2023.1 (January 2023)