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Literature summary extracted from

  • Zhang, X.; Carter, M.; Vetting, M.; Francisco, B.; Zhao, S.; Al-Obaidi, N.; Solbiati, J.; Thiaville, J.; Crecy-Lagard, V.; Jacobson, M.; Almo, S.; Gerlt, J.
    Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars (2016), Proc. Natl. Acad. Sci. USA, 113, E4161-E4169.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.408 0.054
-
 4-phospho-D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.408 0.12
-
 4-phospho-D-threonate pH 8.0, 25°C Cupriavidus necator
1.1.1.408 0.19
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.408 0.2
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Cupriavidus necator
1.1.1.410 0.59
-
 D-erythronate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
1.1.1.410 2.4
-
 D-erythronate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 0.13
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Pectobacterium atrosepticum
1.1.1.411 0.3
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 0.35
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 0.97
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Pectobacterium atrosepticum

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.408 Cupriavidus necator Q0K4F5
-
-
1.1.1.408 Cupriavidus necator DSM 428 Q0K4F5
-
-
1.1.1.408 Salmonella enterica subsp. enterica serovar Typhimurium P58718
-
-
1.1.1.408 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 P58718
-
-
1.1.1.409 Cupriavidus necator Q0K4F5 the enzyme additionally catalyzes the reaction of EC 1.1.1.408
-
1.1.1.409 Cupriavidus necator DSM 428 Q0K4F5 the enzyme additionally catalyzes the reaction of EC 1.1.1.408
-
1.1.1.409 Salmonella enterica subsp. enterica serovar Typhimurium P58718 the enzyme additionally catalyzes the reaction of EC 1.1.1.408
-
1.1.1.409 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 P58718 the enzyme additionally catalyzes the reaction of EC 1.1.1.408
-
1.1.1.410 Cupriavidus necator Q0KBD2
-
-
1.1.1.410 Cupriavidus necator DSM 428 Q0KBD2
-
-
1.1.1.411 Cupriavidus necator Q0KBC7
-
-
1.1.1.411 Cupriavidus necator DSM 428 Q0KBC7
-
-
1.1.1.411 Pectobacterium atrosepticum Q6CZ26
-
-
1.1.1.411 Pectobacterium atrosepticum ATCC BAA-672 Q6CZ26
-
-
2.7.1.217 Cupriavidus necator Q0KBC8
-
-
2.7.1.217 Cupriavidus necator DSM 428 Q0KBC8
-
-
2.7.1.217 Salmonella enterica subsp. enterica serovar Typhimurium Q8ZMG5
-
-
2.7.1.217 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 Q8ZMG5
-
-
5.3.1.35 Cupriavidus necator
-
-
-
5.3.1.35 Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.408 3-dehydro-4-phospho-D-erythronate
-
 Cupriavidus necator glycerone phosphate + CO2 spontaneous reaction ?
1.1.1.408 3-dehydro-4-phospho-D-erythronate
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycerone phosphate + CO2 spontaneous reaction ?
1.1.1.408 3-dehydro-4-phospho-D-erythronate
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 glycerone phosphate + CO2 spontaneous reaction ?
1.1.1.408 3-dehydro-4-phospho-D-erythronate
-
 Cupriavidus necator DSM 428 glycerone phosphate + CO2 spontaneous reaction ?
1.1.1.408 4-hydroxy-L-threonine 4-phosphate + NAD+
-
 Cupriavidus necator 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-hydroxy-L-threonine 4-phosphate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-hydroxy-L-threonine 4-phosphate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-hydroxy-L-threonine 4-phosphate + NAD+
-
 Cupriavidus necator DSM 428 3-amino-2-oxopropyl phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-phospho-D-erythronate + NAD+
-
 Cupriavidus necator glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-phospho-D-erythronate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-phospho-D-erythronate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-phospho-D-erythronate + NAD+
-
 Cupriavidus necator DSM 428 glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-phospho-D-threonate + NAD+
-
 Cupriavidus necator 3-dehydro-4-phospho-D-erythronate + NADH + H+
-
 ?
1.1.1.408 4-phospho-D-threonate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium 3-dehydro-4-phospho-D-erythronate + NADH + H+
-
 ?
1.1.1.408 4-phospho-D-threonate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 3-dehydro-4-phospho-D-erythronate + NADH + H+
-
 ?
1.1.1.408 4-phospho-D-threonate + NAD+
-
 Cupriavidus necator DSM 428 3-dehydro-4-phospho-D-erythronate + NADH + H+
-
 ?
1.1.1.408 4-phospho-D-threonate + NAD+
-
 Cupriavidus necator glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-phospho-D-threonate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-phospho-D-threonate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.408 4-phospho-D-threonate + NAD+
-
 Cupriavidus necator DSM 428 glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.409 3-dehydro-4-phospho-L-threonate
-
 Cupriavidus necator glycerone phosphate + CO2 spontaneous ?
1.1.1.409 3-dehydro-4-phospho-L-threonate
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycerone phosphate + CO2 spontaneous ?
1.1.1.409 4-phospho-D-erythronate + NAD+
-
 Cupriavidus necator 3-dehydro-4-phospho-L-threonate + NADH + H+
-
 ?
1.1.1.409 4-phospho-D-erythronate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium 3-dehydro-4-phospho-L-threonate + NADH + H+
-
 ?
1.1.1.409 4-phospho-D-erythronate + NAD+
-
 Cupriavidus necator glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.409 4-phospho-D-erythronate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium glycerone phosphate + CO2 + NADH + H+ overall reaction ?
1.1.1.410 D-erythronate + NAD+
-
 Cupriavidus necator 2-dehydro-D-erythronate + NADH + H+
-
 ?
1.1.1.410 D-erythronate + NAD+
-
 Cupriavidus necator DSM 428 2-dehydro-D-erythronate + NADH + H+
-
 ?
1.1.1.410 D-erythronate + NADP+
-
 Cupriavidus necator 2-dehydro-D-erythronate + NADPH + H+
-
 ?
1.1.1.410 D-erythronate + NADP+
-
 Cupriavidus necator DSM 428 2-dehydro-D-erythronate + NADPH + H+
-
 ?
1.1.1.411 L-threonate + NAD+
-
 Cupriavidus necator 2-dehydro-L-erythronate + NADH + H+
-
 ?
1.1.1.411 L-threonate + NAD+
-
 Pectobacterium atrosepticum 2-dehydro-L-erythronate + NADH + H+
-
 ?
1.1.1.411 L-threonate + NAD+
-
 Pectobacterium atrosepticum ATCC BAA-672 2-dehydro-L-erythronate + NADH + H+
-
 ?
1.1.1.411 L-threonate + NAD+
-
 Cupriavidus necator DSM 428 2-dehydro-L-erythronate + NADH + H+
-
 ?
1.1.1.411 L-threonate + NADP+
-
 Cupriavidus necator 2-dehydro-L-erythronate + NADPH + H+
-
 ?
1.1.1.411 L-threonate + NADP+
-
 Pectobacterium atrosepticum 2-dehydro-L-erythronate + NADPH + H+
-
 ?
1.1.1.411 L-threonate + NADP+
-
 Pectobacterium atrosepticum ATCC BAA-672 2-dehydro-L-erythronate + NADPH + H+
-
 ?
1.1.1.411 L-threonate + NADP+
-
 Cupriavidus necator DSM 428 2-dehydro-L-erythronate + NADPH + H+
-
 ?
2.7.1.217 ATP + 3-dehydro-D-erythronate
-
 Cupriavidus necator ADP + 3-dehydro-4-phospho-D-erythronate
-
 ?
2.7.1.217 ATP + 3-dehydro-D-erythronate
-
 Salmonella enterica subsp. enterica serovar Typhimurium ADP + 3-dehydro-4-phospho-D-erythronate
-
 ?
2.7.1.217 ATP + 3-dehydro-D-erythronate
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 ADP + 3-dehydro-4-phospho-D-erythronate
-
 ?
2.7.1.217 ATP + 3-dehydro-D-erythronate
-
 Cupriavidus necator DSM 428 ADP + 3-dehydro-4-phospho-D-erythronate
-
 ?
2.7.1.217 ATP + 3-dehydro-L-erythronate
-
 Cupriavidus necator ADP + 3-dehydro-4-phospho-L-erythronate
-
 ?
2.7.1.217 ATP + 3-dehydro-L-erythronate
-
 Salmonella enterica subsp. enterica serovar Typhimurium ADP + 3-dehydro-4-phospho-L-erythronate
-
 ?
2.7.1.217 ATP + 3-dehydro-L-erythronate
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 ADP + 3-dehydro-4-phospho-L-erythronate
-
 ?
2.7.1.217 ATP + 3-dehydro-L-erythronate
-
 Cupriavidus necator DSM 428 ADP + 3-dehydro-4-phospho-L-erythronate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.408 D-threonate 4-phosphate dehydrogenase
-
 Cupriavidus necator
1.1.1.408 D-threonate 4-phosphate dehydrogenase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.408 DUF1537
-
 Cupriavidus necator
1.1.1.408 DUF1537
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.408 pdxA2
-
 Cupriavidus necator
1.1.1.408 pdxA2
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.409 DUF1537
-
 Cupriavidus necator
1.1.1.409 DUF1537
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.409 pdxA2
-
 Cupriavidus necator
1.1.1.409 pdxA2
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.410 D-erythronate 2-dehydrogenase
-
 Cupriavidus necator
1.1.1.410 denD
-
 Cupriavidus necator
1.1.1.411 L-threonate dehydrogenase
-
 Cupriavidus necator
1.1.1.411 L-threonate dehydrogenase
-
 Pectobacterium atrosepticum
1.1.1.411 ltnD
-
 Cupriavidus necator
1.1.1.411 ltnD
-
 Pectobacterium atrosepticum
2.7.1.217 3-oxo-tetronate kinase
-
 Cupriavidus necator
2.7.1.217 3-oxo-tetronate kinase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.217 otnK
-
 Cupriavidus necator
2.7.1.217 otnK
-
 Salmonella enterica subsp. enterica serovar Typhimurium
5.3.1.35 2-oxo-tetronate isomerase
-
 Cupriavidus necator
5.3.1.35 OtnI
-
 Cupriavidus necator

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.408 0.35
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Cupriavidus necator
1.1.1.408 0.37
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.408 3.4
-
 4-phospho-D-threonate pH 8.0, 25°C Cupriavidus necator
1.1.1.408 8.9
-
 4-phospho-D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.410 3
-
 D-erythronate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
1.1.1.410 19
-
 D-erythronate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 2.2
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 4.7
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Pectobacterium atrosepticum
1.1.1.411 29
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 54
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Pectobacterium atrosepticum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.410 NAD+ NAD+ is preferred over NADP+ Cupriavidus necator
1.1.1.410 NADP+ NAD+ is preferred over NADP+ Cupriavidus necator
1.1.1.411 NAD+ NAD+ is preferred over NADP+ Cupriavidus necator
1.1.1.411 NAD+ NAD+ is preferred over NADP+ Pectobacterium atrosepticum
1.1.1.411 NADP+ NAD+ is preferred over NADP+ Cupriavidus necator
1.1.1.411 NADP+ NAD+ is preferred over NADP+ Pectobacterium atrosepticum

General Information

EC Number General Information Comment Organism
1.1.1.408 physiological function members of the DUF1537 family are ATP-dependent kinases that participate in catabolic pathways for four-carbon acid sugars. PdxA2 participates in a pathway for the conversion of D-threonate to dihydroxyacetone phosphate and CO2. A strain lacking PdxA2 activity is unable to use D-threonate as a carbon source Cupriavidus necator
2.7.1.217 physiological function involved in utilization of L-threonate and D-erythronate, with different dehydrogenases generating the 2-oxo-tetronate that is isomerized to 3-oxo-tetronate by OtnI, phosphorylated to 3-oxo-tetronate 4-phosphate by OtnK, and decarboxylated to DHAP and CO2 Cupriavidus necator
2.7.1.217 physiological function involved in utilization of L-threonate and D-erythronate, with different dehydrogenases generating the 2-oxo-tetronate that is isomerized to 3-oxo-tetronate by OtnI, phosphorylated to 3-oxo-tetronate 4-phosphate by OtnK, and decarboxylated to DHAP and CO2 Salmonella enterica subsp. enterica serovar Typhimurium

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.1.1.408 1.8
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Cupriavidus necator
1.1.1.408 1.9
-
 4-hydroxy-L-threonine 4-phosphate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.408 29
-
 4-phospho-D-threonate pH 8.0, 25°C Cupriavidus necator
1.1.1.408 160
-
 4-phospho-D-threonate pH 8.0, 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.410 1.2
-
 D-erythronate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
1.1.1.410 33
-
 D-erythronate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 4.8
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Pectobacterium atrosepticum
1.1.1.411 7.5
-
 L-threonate cosubstrate NADP+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 85
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Cupriavidus necator
1.1.1.411 410
-
 L-threonate cosubstrate NAD+, pH 8.0, 25°C Pectobacterium atrosepticum