EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.338 | desmethylxanthohumol | competitive with respect to xanthohumol | Humulus lupulus | |
2.1.1.338 | S-adenosyl-L-homocysteine | - |
Humulus lupulus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.338 | 0.018 | - |
desmethylxanthohumol | pH 7.5, 30°C | Humulus lupulus | |
2.1.1.338 | 0.286 | - |
S-adenosyl-L-methionine | pH 7.5, 30°C | Humulus lupulus | |
2.1.1.339 | 0.019 | - |
resveratrol | pH 7.5, 30°C | Humulus lupulus | |
2.1.1.339 | 0.023 | - |
desmethylxanthohumol | pH 7.5, 30°C | Humulus lupulus | |
2.1.1.339 | 0.031 | - |
xanthohumol | pH 7.5, 30°C | Humulus lupulus | |
2.1.1.339 | 0.034 | - |
S-adenosyl-L-methionine | pH 7.5, 30°C | Humulus lupulus | |
2.1.1.339 | 0.237 | - |
chalconaringenin | pH 7.5, 30°C | Humulus lupulus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.338 | additional information | bivalent cations (Mg2+, Fe2+, Zn2+, Cu2+, Ca2+, and Co2+) are not required for activity | Humulus lupulus | |
2.1.1.339 | additional information | bivalent cations (Mg2+, Fe2+, Zn2+, Cu2+, Ca2+, and Co2+) are not required for activity | Humulus lupulus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.1.338 | 39265 | - |
- |
Humulus lupulus |
2.1.1.338 | 76000 | - |
gel filtration | Humulus lupulus |
2.1.1.339 | 64000 | - |
gel filtration | Humulus lupulus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.338 | Humulus lupulus | B0ZB55 | - |
- |
2.1.1.339 | Humulus lupulus | B0ZB56 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.338 | S-adenosyl-L-methionine + caffeic acid | - |
Humulus lupulus | S-adenosyl-L-homocysteine + ? | 7% of the activity with desmethylxanthohumol | ? | |
2.1.1.338 | S-adenosyl-L-methionine + desmethylxanthohumol | - |
Humulus lupulus | S-adenosyl-L-homocysteine + xanthohumol | - |
? | |
2.1.1.338 | S-adenosyl-L-methionine + xanthogalenol | 445% of the activity with desmethylxanthohumol | Humulus lupulus | S-adenosyl-L-homocysteine + ? | - |
? | |
2.1.1.339 | S-adenosyl-L-methionine + 2',4-dihydroxychalcone | 45% of the activity with isoliquiritigenin | Humulus lupulus | S-adenosyl-L-homocysteine + ? | - |
? | |
2.1.1.339 | S-adenosyl-L-methionine + butein | 50% of the activity with isoliquiritigenin | Humulus lupulus | S-adenosyl-L-homocysteine + ? | - |
? | |
2.1.1.339 | S-adenosyl-L-methionine + chalconaringenin | 40% of the activity with isoliquiritigenin | Humulus lupulus | S-adenosyl-L-homocysteine + ? | - |
? | |
2.1.1.339 | S-adenosyl-L-methionine + desmethylxanthohumol | 25% of the activity with isoliquiritigenin | Humulus lupulus | S-adenosyl-L-homocysteine + 4'-O-methyl-desmethylxanthohumol | - |
? | |
2.1.1.339 | S-adenosyl-L-methionine + guaiacol | 42% of the activity with isoliquiritigenin | Humulus lupulus | S-adenosyl-L-homocysteine + ? | - |
? | |
2.1.1.339 | S-adenosyl-L-methionine + isoliquiritigenin | - |
Humulus lupulus | S-adenosyl-L-homocysteine + ? | - |
? | |
2.1.1.339 | S-adenosyl-L-methionine + resveratrol | 87% of the activity with isoliquiritigenin | Humulus lupulus | S-adenosyl-L-homocysteine + ? | - |
? | |
2.1.1.339 | S-adenosyl-L-methionine + xanthohumol | 36% of the activity with isoliquiritigenin | Humulus lupulus | S-adenosyl-L-homocysteine + 4'-O-methylxanthohumol | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.1.338 | dimer | 2 * 39265, calculated | Humulus lupulus |
2.1.1.339 | dimer | 2 * 39792, calculated | Humulus lupulus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.338 | OMT1 | - |
Humulus lupulus |
2.1.1.338 | S-adenosyl-L-methionine-dependent O-methyltransferase | - |
Humulus lupulus |
2.1.1.339 | OMT2 | - |
Humulus lupulus |
2.1.1.339 | S-adenosyl-L-methionine-dependent O-methyltransferase | - |
Humulus lupulus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.338 | 30 | 37 | - |
Humulus lupulus |
2.1.1.339 | 39 | - |
- |
Humulus lupulus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.1.1.338 | 9 | - |
- |
Humulus lupulus |
2.1.1.339 | 8.5 | - |
- |
Humulus lupulus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.338 | 0.002 | - |
desmethylxanthohumol | pH 7.5, 30°C | Humulus lupulus | |
2.1.1.338 | 0.098 | - |
S-adenosyl-L-homocysteine | pH 7.5, 30°C | Humulus lupulus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.338 | physiological function | OMT1 performs the final reaction in xanthohumol biosynthesis by methylating desmethylxanthohumol to form xanthohumol | Humulus lupulus |