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Literature summary extracted from

  • Yunes, R.; Casas, S.; Gaglio, E.; Cabrera, R.
    Progesterone exerts a neuromodulatory effect on turning behavior of hemiparkinsonian male rats: expression of 3alpha-hydroxysteroid oxidoreductase and allopregnanolone as suggestive of GABA A receptors involvement (2015), Parkinsons Dis., 2015, 431690.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.50 pregn-4-en-3,20-dione + NADPH + H+ Rattus norvegicus progesterone 3alpha-hydroxypregn-4-en-20-one + NADP+ allopregnanolone r
1.1.1.50 pregn-4-en-3,20-dione + NADPH + H+ Rattus norvegicus Sprague-Dawley progesterone 3alpha-hydroxypregn-4-en-20-one + NADP+ allopregnanolone r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.50 Rattus norvegicus P23457
-
-
1.1.1.50 Rattus norvegicus Sprague-Dawley P23457
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.50 brain from male rats Rattus norvegicus
-
1.1.1.50 striatum
-
 Rattus norvegicus
-
1.1.1.50 substantia nigra
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.50 pregn-4-en-3,20-dione + NADPH + H+ progesterone Rattus norvegicus 3alpha-hydroxypregn-4-en-20-one + NADP+ allopregnanolone r
1.1.1.50 pregn-4-en-3,20-dione + NADPH + H+ progesterone Rattus norvegicus Sprague-Dawley 3alpha-hydroxypregn-4-en-20-one + NADP+ allopregnanolone r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.50 3alpha-HSOR
-
 Rattus norvegicus
1.1.1.50 3alpha-hydroxysteroid oxidoreductase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.50 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.50 6.5
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.50 NADP+
-
 Rattus norvegicus
1.1.1.50 NADPH
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.1.1.50 Rattus norvegicus the 3alpha-HSOR mRNA ipsilateral expression of progesterone-treated hemiparkinsonian animals is significantly augmented compared to sham and hemiparkinsonian rats. On the other hand, 3alpha-HSOR mRNA expression is no different among groups when substantia nigra samples contralateral to lesion are considered additional information

General Information

EC Number General Information Comment Organism
1.1.1.50 additional information effect of progesterone in lesions, caused by neurotoxic 6-hydroxydopamine hydrobromide, on the contralateral turning behavior, overview Rattus norvegicus