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Literature summary extracted from

  • Arimori, T.; Tamaoki, H.; Nakamura, T.; Kamiya, H.; Ikemizu, S.; Takagi, Y.; Ishibashi, T.; Harashima, H.; Sekiguchi, M.; Yamagata, Y.
    Diverse substrate recognition and hydrolysis mechanisms of human NUDT5 (2011), Nucleic Acids Res., 39, 8972-8983.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.13 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.1.13 complexed with 8-oxo-dGMP, 8-oxo-dGDP and 8-oxo-dADP, hanging drop vapor diffusion method, using 0.8 M NaH2PO4/1.2M K2HPO4 and 0.1 M acetate (pH 4.5), and 0.2M ammonium acetate, 35-40% (w/v) polyethylene glycol 3350 and 0.1 M sodium citrate (pH 6.2) Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.13 Mn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.13 ADP-D-ribose + H2O Homo sapiens
-
AMP + D-ribose 5-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.13 Homo sapiens Q9UKK9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.1.13 Ni-Sepharose 6 column chromatography, HisTrap column chromatography, and Superdex 75 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.13 8-oxo-dADP + H2O
-
Homo sapiens ?
-
?
3.6.1.13 8-oxo-dGDP + H2O
-
Homo sapiens ?
-
?
3.6.1.13 ADP-D-ribose + H2O
-
Homo sapiens AMP + D-ribose 5-phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.13 ADP-ribose pyrophosphatase
-
Homo sapiens
3.6.1.13 ADPRase
-
Homo sapiens
3.6.1.13 NUDT5
-
Homo sapiens